Fig. 3
From: Tau reduction attenuates autism-like features in Fmr1 knockout mice
Genetically reducing Tau reverses spine abnormality in Fmr1−/y mice. A Representative projection images of dendritic spines from cortical neurons from WT, Fmr1−/y, and Fmr1−/y;Mapt± mice (2.5-month-old, FVB;C57BL/6/SV129 mixed background). Mature and immature dendritic spines were indicated by red and green arrowheads, respectively. Scale bars: 5 μm. B, C Comparisons of spine density (B) and ratios of mature and immature spines (C) of cortical neurons. One-way ANOVA followed by Tukey’s post hoc test. WT: n = 4; Mapt±: n = 4; Fmr1−/y: n = 4; Fmr1−/y;Mapt±: n = 4. ***p < 0.001, ****p < 0.0001