Fig. 4

Glucose and hypothalamic hormone mRNA levels after LPS and WBH protocols. A Blood glucose levels (mmol/L) at 4 h after LPS or WBH, shown as mean ± SEM (RT, LPS n = 8, WBH n = 10). B Blood glucose levels (mmol/L) measured by serial tail vein sampling from 1 h pre- to 24 h post-LPS or WBH treatment (n = 8). C Level of expression of mRNA for hypothalamic hormones at 4 h after LPS or WBH. Data are shown as mean ± SEM, with each data point representing one animal. Time course analysis was performed using two-way repeated measures ANOVA followed by Bonferroni post hoc analyses. All other analyses performed by one-way ANOVA followed Bonferroni’s test. * versus RT; # versus LPS. Abbreviations: RT, room temperature; LPS, bacterial endotoxin, 250 µg/kg; WBH, whole-body hyperthermia