Fig. 5

Decrease of inhibitory interneurons in Pv-Cre^+/− Shank3^Fl/Wt mice. A Quantification and representative images of the number of PV neurons in the hippocampus. Pv-Cre^+/− Shank3^Fl/Wt mice show a reduction of Parvalbumin interneurons in the dentate gyrus of the hippocampus. Data from the CA1 were analyzed by unpaired, two-tailed Student’s t-test; quantification of the CA3 and DG were analyzed by two-tailed Mann–Whitney test; n = 17 Pv-Cre^+/− Shank3^Wt/Wt, n = 16 Pv-Cre^+/− Shank3^Fl/Wt; *** p < 0.001; n = number of bilateral slides analyzed; 3 animals used for each group. CA1 = Cornu Ammonis-1; CA3 = Cornu Ammonis-3; DG = dentate gyrus. B Quantification and representative images of the number of PV neurons in the medial prefrontal cortex. Data were analyzed by unpaired, two-tailed Student’s t-test; n = 9 Pv-Cre^+/− Shank3^Wt/Wt, n = 8 Pv-Cre^+/− Shank3^Fl/Wt; ** p < 0.01; n = number of bilateral slides analyzed; 3 animals used for each group. C Quantification and representative images of the number of PV neurons in the visual cortex. Data were analyzed by unpaired, two-tailed Student’s t-test with Welch’s correction; n = 8 Pv-Cre ± Shank3Wt/Wt, n = 11 Pv-Cre ± Shank3Fl/Wt; n = number of bilateral slides analyzed; 3 animals used for each group