Algorithm no | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Compartment and analyte | Plasma protein adduct residues | Plasma amino acids | Plasma protein adduct residues and amino acids | Urinary amino acids |
Features | CML, 3DG-H, CMA, and DT | CML and CMA | CML, 3DG-H, CMA, and DT residues with G-H1 and GSA free adducts | GSA and pyrraline free adducts |
Accuracy (%) | 88.3 (85.5–91.2) | 74.8 (71.7–77.9) | 89.0 (87.0–91.0) | 76.8 (74.6–79.0) |
Sensitivity (%) | 91.9 (89.1–94.6) | 80.5 (75.1–86.0) | 90.4 (87.7–93.1) | 77.1 (73.4–80.8) |
Specificity (%) | 83.9 (79.3–88.4) | 67.1 (58.9–75.4) | 87.3 (84.1–90.5) | 76.4 (72.0–80.8) |
AUROC | 0.94 (0.91–0.96) | 0.80 (0.77–0.83) | 0.95 (0.94–0.96) | 0.79 (0.76–0.81) |
Positive likelihood ratio | 5.69 (4.49–6.89) | 2.85 (2.16–3.55) | 7.23 (6.09–8.38) | 4.16 (2.88–5.44) |
Negative likelihood ratio | 0.10 (0.07–0.13) | 0.28 (0.21–0.35) | 0.11 (0.08–0.14) | 0.30 (0.25–0.34) |
Positive predictive value (%) | 88.2 (85.0–91.4) | 77.1 (72.9–81.4) | 90.2 (87.9–92.5) | 80.6 (77.6–83.5) |
Negative predictive value (%) | 89.1 (85.5–92.6) | 75.0 (70.6–79.4) | 88.0 (85.1–91.0) | 73.7 (71.0–76.5) |
F score | 0.90 (0.87–0.92) | 0.78 (0.75–0.81) | 0.90 (0.88–0.92) | 0.78 (0.76–0.81) |