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Table 6 Renal clearance of amino acids

From: Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis

Amino acid

Renal clearance (mL/mg creatinine)

 

Healthy controls

ASD

P value

Ala

1.03 (0.746–1.712)

1.27 (0.890–1.65)

 

Arg

0.011 (0.009–0.015)

0.008 (0.006–0.010)

0.0019*

Asn

2.80 (2.22–4.76)

4.30 (3.05–7.14)

0.0055

Asp

3.81 (3.04–4.96)

4.73 (2.92–7.82)

 

Cys (total)

0.646 (0.518–0.812)

0.629 (0.452–1.133)

 

Gln

1.18 (0.913–1.53)

1.54 (1.14–1.96)

0.025

Glu

0.210 (0.158–0.304)

0.243 (0.179–0.357

0.049

Gly

0.0050 (0.002–0.009)

0.0067 (0.004–0.029)

0.018

His

0.029 (0.024–0.040)

0.040 (0.027–0.053)

 

IIe

0.262 (0.192–0.347)

0.354 (0.256–0.441)

0.0116

Leu

0.358 ± 0.135

0.402 ± 0.105

 

Lys

0.011 (0.005–0.018)

0.0071 (0.005–0.011)

 

Met

0.0066 ± 0.0015

0.0056 ± 0.0023

 

Phe

1.32 (0.959–2.02)

1.65 (1.33–1.95)

 

Pro

0.077 ± 0.031

0.104 ± 0.039

0.0138

Ser

3.66 (2.95–4.79)

5.22 (3.99–6.78)

0.0081

Thr

2.023 ± 0.765

2.44 ± 1.05

 

Trp

0.209 (0.155–0.242)

0.287 (0.166–0.497)

0.010

Tyr

0.0209 (0.016–0.025)

0.015 (0.012–0.025)

 

Val

0.0017 (0.0014–0.0022)

0.0016 (0.0013–0.0026)

 
  1. Data are mean ± SD or median (lower–upper quartile); healthy controls, n = 21, and ASD, n = 27. Significance: t test for parametric data and Mann-Whitney U for non-parametric data
  2. *P < 0.05, after Bonferroni correction of 20 applied