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Fig. 1 | Molecular Autism

Fig. 1

From: Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits

Fig. 1

Pten mice have increased TH and P-CREB in the frontal cortex and striatum. a NLS-like region of Pten and the missense mutations (Pten, indicated in bold) created in the NLS-like region. b Western blotting results show elevated AKT and TH signaling, together with diminished Pten expression in the cerebral hemisphere of the Ptenm3m4/m3m4 mutant mice. c Coronal section of the forebrain immunolabeled with the antibody against tyrosine hydroxylase (TH). Note the increased density of the TH-positive fibers in the striatum and frontal cortex of the Ptenm3m4/m3m4 mutant mice. d Coronal section of the forebrain immunolabeled with the antibody against dopamine D2 receptors (D2R). Images were acquired at (top) ×5 and (bottom) ×20 magnification. Scale bar for top panels is 200 μm and bottom panels is 50 μm

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Molecular Autism

ISSN: 2040-2392