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Figure 3 | Molecular Autism

Figure 3

From: Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism

Figure 3

Expression ofRORAin the human orbital frontal cortex of age-matched females and males as a function of developmental stage. (A)RORA expression in the orbital frontal cortex (OFC) of age-matched females (F) and males (M) before birth (BB), and at different intervals after birth (birth to 18 years and ≥19 years) using RNAseq data from the BrainSpan Atlas of the Developing Human Brain [32]. The number of females (F) and males (M) included in each developmental period were: BB (6 F:5 M), birth-18 (3 F:3 M), and ≥ 19 (3 F:3 M). (B) The table shows the female-to-male (F/M) expression ratios and associated two-tailed P values, t-values, and effect sizes for differences between the group means for different developmental periods. *For this comparison, a female whose age difference exceeded (by one year) the age-matching criteria of ± 3 years with respect to the male group was excluded from the analyses.

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Molecular Autism

ISSN: 2040-2392