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  1. Beyond the core symptoms of autism spectrum disorder (ASD), associated symptoms of anxiety can cause substantial impairment for individuals affected by ASD and those who care for them.

    Authors: Paul D Chamberlain, Jacqui Rodgers, Michael J Crowley, Sarah E White, Mark H Freeston and Mikle South

    Citation: Molecular Autism 2013 4:31

    Content type: Research

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  2. Since RNA expression differences have been reported in autism spectrum disorder (ASD) for blood and brain, and differential alternative splicing (DAS) has been reported in ASD brains, we determined if there wa...

    Authors: Boryana S Stamova, Yingfang Tian, Christine W Nordahl, Mark D Shen, Sally Rogers, David G Amaral and Frank R Sharp

    Citation: Molecular Autism 2013 4:30

    Content type: Research

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  3. Deletion of the Williams-Beuren syndrome (WBS) critical region (WBSCR), at 7q11.23, causes a developmental disorder commonly characterized by hypersociability and excessive talkativeness and often considered t...

    Authors: Sylvie Tordjman, George M Anderson, David Cohen, Solenn Kermarrec, Michèle Carlier, Yvan Touitou, Pascale Saugier-Veber, Céline Lagneaux, Claire Chevreuil and Alain Verloes

    Citation: Molecular Autism 2013 4:29

    Content type: Research

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  4. Rare genetic variation is an important class of autism spectrum disorder (ASD) risk factors and can implicate biological networks for investigation. Altered serotonin (5-HT) signaling has been implicated in AS...

    Authors: Nicholas G Campbell, Chong-Bin Zhu, Kathryn M Lindler, Brian L Yaspan, Emily Kistner-Griffin, William A Hewlett, Christopher G Tate, Randy D Blakely and James S Sutcliffe

    Citation: Molecular Autism 2013 4:28

    Content type: Research

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  5. Autism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, ...

    Authors: Jordan M Ramsey, Paul C Guest, Jantine AC Broek, Jeffrey C Glennon, Nanda Rommelse, Barbara Franke, Hassan Rahmoune, Jan K Buitelaar and Sabine Bahn

    Citation: Molecular Autism 2013 4:27

    Content type: Research

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  6. We recently reported a terminal deletion of approximately 2.4 Mb at chromosome 8p23.2-pter in a boy with autism. The deleted region contained the DLGAP2 gene that encodes the neuronal post-synaptic density protei...

    Authors: Wei-Hsien Chien, SusanShur-Fen Gau, Hsiao-Mei Liao, Yen-Nan Chiu, Yu-Yu Wu, Yu-Shu Huang, Wen-Che Tsai, Ho-Min Tsai and Chia-Hsiang Chen

    Citation: Molecular Autism 2013 4:26

    Content type: Research

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  7. Patients with anorexia may have elevated autistic traits. In this study, we tested test whether patients with anorexia nervosa (anorexia) have an elevated score on a dimensional measure of autistic traits, the...

    Authors: Simon Baron-Cohen, Tony Jaffa, Sarah Davies, Bonnie Auyeung, Carrie Allison and Sally Wheelwright

    Citation: Molecular Autism 2013 4:24

    Content type: Research

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  8. Aberrant brain connectivity, especially with long-distance underconnectivity, has been recognized as a candidate pathophysiology of autism spectrum disorders. However, a number of diffusion tensor imaging stud...

    Authors: Yuta Aoki, Osamu Abe, Yasumasa Nippashi and Hidenori Yamasue

    Citation: Molecular Autism 2013 4:25

    Content type: Research

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  9. Comparative gene expression profiling analysis is useful in discovering differentially expressed genes associated with various diseases, including mental disorders. Autism spectrum disorders (ASD) are a group ...

    Authors: Wei-Hsien Chien, SusanShur-Fen Gau, Chun-Houh Chen, Wen-Che Tsai, Yu-Yu Wu, Po-Hsu Chen, Chi-Yung Shang and Chia-Hsiang Chen

    Citation: Molecular Autism 2013 4:23

    Content type: Research

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  10. The human oxytocin receptor (hOXTR) is implicated in the etiology of autism spectrum disorders (ASDs) and is a potential target for therapeutic intervention. Several studies have reported single-nucleotide pol...

    Authors: Wen-Jie Ma, Minako Hashii, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Masakazu Yamagishi, Haruhiro Higashida and Shigeru Yokoyama

    Citation: Molecular Autism 2013 4:22

    Content type: Research

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  11. Candidate genes associated with idiopathic forms of autism overlap with other disorders including fragile X syndrome. Our laboratory has previously shown reduction in fragile X mental retardation protein (FMRP...

    Authors: SHossein Fatemi, Timothy D Folsom, Rachel E Kneeland, Mahtab K Yousefi, Stephanie B Liesch and Paul D Thuras

    Citation: Molecular Autism 2013 4:21

    Content type: Research

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  12. The objective of this study was to examine differences in episodic memory retrieval between individuals with autism spectrum disorder (ASD) and typically developing (TD) individuals. Previous studies have show...

    Authors: Hidetsugu Komeda, Hirotaka Kosaka, Daisuke N Saito, Keisuke Inohara, Toshio Munesue, Makoto Ishitobi, Makoto Sato and Hidehiko Okazawa

    Citation: Molecular Autism 2013 4:20

    Content type: Research

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  13. Adhesion molecules, such as platelet-endothelial adhesion molecule-1 (PECAM-1), platelet selectin (P-selectin), endothelial selectin (E-selectin), intracellular adhesion molecule-1 (ICAM-1), and vascular cell ...

    Authors: Yosuke Kameno, Keiko Iwata, Hideo Matsuzaki, Taishi Miyachi, Kenji J Tsuchiya, Kaori Matsumoto, Yasuhide Iwata, Katsuaki Suzuki, Kazuhiko Nakamura, Masato Maekawa, Masatsugu Tsujii, Toshirou Sugiyama and Norio Mori

    Citation: Molecular Autism 2013 4:19

    Content type: Short report

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  14. 22q13 deletion syndrome, also known as Phelan-McDermid syndrome, is a neurodevelopmental disorder characterized by intellectual disability, hypotonia, delayed or absent speech, and autistic features. SHANK3 has b...

    Authors: Latha Soorya, Alexander Kolevzon, Jessica Zweifach, Teresa Lim, Yuriy Dobry, Lily Schwartz, Yitzchak Frank, A Ting Wang, Guiqing Cai, Elena Parkhomenko, Danielle Halpern, David Grodberg, Benjamin Angarita, Judith P Willner, Amy Yang, Roberto Canitano…

    Citation: Molecular Autism 2013 4:18

    Content type: Research

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  15. Autism spectrum disorders (ASDs) are relatively common neurodevelopmental conditions whose biological basis has been incompletely determined. Several biochemical markers have been associated with ASDs, but the...

    Authors: Luigi Boccuto, Chin-Fu Chen, Ayla R Pittman, Cindy D Skinner, Heather J McCartney, Kelly Jones, Barry R Bochner, Roger E Stevenson and Charles E Schwartz

    Citation: Molecular Autism 2013 4:16

    Content type: Research

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  16. Fragile X syndrome (FXS) is a common inherited form of intellectual disability caused by loss of function of the fragile X mental retardation protein. Recent animal studies suggest that upregulated downstream ...

    Authors: Talakad G Lohith, Emily K Osterweil, Masahiro Fujita, Kimberly J Jenko, Mark F Bear and Robert B Innis

    Citation: Molecular Autism 2013 4:15

    Content type: Research

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  17. We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). Our independent cohort studies have consis...

    Authors: Tewarit Sarachana and Valerie W Hu

    Citation: Molecular Autism 2013 4:14

    Content type: Research

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  18. Since Kanner’s first description of autism there have been a number of changes in approaches to diagnosis with certain key continuities . Since the Fourth edition of the Diagnostic and Statistical Manual (DSM-...

    Authors: Fred R Volkmar and Brian Reichow

    Citation: Molecular Autism 2013 4:13

    Content type: Review

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  19. We are fortunate to have invited commentaries from the laboratories of Dr Cathy Lord and Dr Fred Volkmar offering their perspectives on the new Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 cri...

    Authors: Joseph D Buxbaum and Simon Baron-Cohen

    Citation: Molecular Autism 2013 4:11

    Content type: Editorial

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  20. Haploinsufficiency of SHANK3, due to either hemizygous gene deletion (termed 22q13 deletion syndrome or Phelan-McDermid syndrome) or to gene mutation, accounts for about 0.5% of the cases of autism spectrum disor...

    Authors: Ozlem Bozdagi, Teresa Tavassoli and Joseph D Buxbaum

    Citation: Molecular Autism 2013 4:9

    Content type: Short report

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  21. Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental disorders that affect 1 in 88 children in the US. Previous exome sequencing studies on family trios have implicated a role for...

    Authors: Lingling Shi, Xu Zhang, Ryan Golhar, Frederick G Otieno, Mingze He, Cuiping Hou, Cecilia Kim, Brendan Keating, Gholson J Lyon, Kai Wang and Hakon Hakonarson

    Citation: Molecular Autism 2013 4:8

    Content type: Research

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  22. The prevalence of autism spectrum conditions (ASC) is 1% in developed countries, but little data are available from mainland China, Hong Kong and Taiwan. This study synthesizes evidence relating to the prevale...

    Authors: Xiang Sun, Carrie Allison, Fiona E Matthews, Stephen J Sharp, Bonnie Auyeung, Simon Baron-Cohen and Carol Brayne

    Citation: Molecular Autism 2013 4:7

    Content type: Review

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  23. Accumulating evidence suggests that dysfunction in the glutamatergic system may underlie the pathophysiology of autism. The anterior cingulate cortex (ACC) has been implicated in autism as well as in glutamate...

    Authors: Chie Shimmura, Katsuaki Suzuki, Yasuhide Iwata, Kenji J Tsuchiya, Koji Ohno, Hideo Matsuzaki, Keiko Iwata, Yosuke Kameno, Taro Takahashi, Tomoyasu Wakuda, Kazuhiko Nakamura, Kenji Hashimoto and Norio Mori

    Citation: Molecular Autism 2013 4:6

    Content type: Research

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  24. Autism spectrum disorder (ASD) is reported in 30 to 60% of patients with tuberous sclerosis complex (TSC) but shared genetic mechanisms that exist between TSC-associated ASD and idiopathic ASD have yet to be d...

    Authors: Samira Bahl, Colby Chiang, Roberta L Beauchamp, Benjamin M Neale, Mark J Daly, James F Gusella, Michael E Talkowski and Vijaya Ramesh

    Citation: Molecular Autism 2013 4:5

    Content type: Research

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  25. Vision in people with autism spectrum conditions (ASC) is reported to be different from people without ASC, but the neural level at which the differences begin to occur is not yet known. Here we examine two va...

    Authors: Keziah Latham, Susana L Chung, Peter M Allen, Teresa Tavassoli and Simon Baron-Cohen

    Citation: Molecular Autism 2013 4:4

    Content type: Short report

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  26. Mutations in MECP2 encoding methyl-CpG-binding protein 2 (MeCP2) cause the X-linked neurodevelopmental disorder Rett syndrome. Rett syndrome patients exhibit neurological symptoms that include irregular breathing...

    Authors: Dag H Yasui, Huichun Xu, Keith W Dunaway, Janine M LaSalle, Lee-Way Jin and Izumi Maezawa

    Citation: Molecular Autism 2013 4:3

    Content type: Research

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  27. Autism Spectrum Conditions (ASC) are a set of pervasive neurodevelopmental conditions characterized by a wide range of lifelong signs and symptoms. Recent explanatory models of autism propose abnormal neural c...

    Authors: Ana Catarino, Alexandre Andrade, Owen Churches, Adam P Wagner, Simon Baron-Cohen and Howard Ring

    Citation: Molecular Autism 2013 4:1

    Content type: Research

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  28. Alternation of synaptic homeostasis is a biological process whose disruption might predispose children to autism spectrum disorders (ASD). Calcium channel genes (CCG) contribute to modulating neuronal function...

    Authors: Ake Tzu-Hui Lu, Xiaoxian Dai, Julian A Martinez-Agosto and Rita M Cantor

    Citation: Molecular Autism 2012 3:18

    Content type: Research

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  29. Studies of prenatal exposure to sex steroid hormones predict autistic traits in children at 18 to 24 and at 96 months of age. However, it is not known whether postnatal exposure to these hormones has a similar...

    Authors: Bonnie Auyeung, Jag Ahluwalia, Lynn Thomson, Kevin Taylor, Gerald Hackett, Kieran J O’Donnell and Simon Baron-Cohen

    Citation: Molecular Autism 2012 3:17

    Content type: Short report

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  30. There are no effective medications for the treatment of social cognition/function deficits in autism spectrum disorder (ASD), and adult intervention literature in this area is sparse. Emerging data from animal...

    Authors: Evdokia Anagnostou, Latha Soorya, William Chaplin, Jennifer Bartz, Danielle Halpern, Stacey Wasserman, A Ting Wang, Lauren Pepa, Nadia Tanel, Azadeh Kushki and Eric Hollander

    Citation: Molecular Autism 2012 3:16

    Content type: Research

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  31. Reduced activity during cognitively demanding tasks has been reported in the default mode network in typically developing controls and individuals with autism. However, no study has investigated the default mo...

    Authors: Michael D Spencer, Lindsay R Chura, Rosemary J Holt, John Suckling, Andrew J Calder, Edward T Bullmore and Simon Baron-Cohen

    Citation: Molecular Autism 2012 3:15

    Content type: Short report

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  32. While models of autism spectrum conditions (ASC) are emerging at the genetic level of analysis, clear models at higher levels of analysis, such as neuroanatomy, are lacking. Here we examine agenesis of the cor...

    Authors: Michael V Lombardo, Bhismadev Chakrabarti, Meng-Chuan Lai and Simon Baron-Cohen

    Citation: Molecular Autism 2012 3:14

    Content type: Research

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  33. Autism spectrum disorders (ASD) are defined by impairment in reciprocal social interaction and flexible adaptation to the environment. This study compared physiological stress in children with and without ASD ...

    Authors: Blythe A Corbett, Clayton W Schupp and Kimberly E Lanni

    Citation: Molecular Autism 2012 3:13

    Content type: Research

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  34. Mitochondrial dysfunction (MtD) has been observed in approximately five percent of children with autism spectrum disorders (ASD). MtD could impair highly energy-dependent processes such as neurodevelopment, th...

    Authors: Ayyappan Anitha, Kazuhiko Nakamura, Ismail Thanseem, Kazuo Yamada, Yoshimi Iwayama, Tomoko Toyota, Hideo Matsuzaki, Taishi Miyachi, Satoru Yamada, Masatsugu Tsujii, Kenji J Tsuchiya, Kaori Matsumoto, Yasuhide Iwata, Katsuaki Suzuki, Hironobu Ichikawa, Toshiro Sugiyama…

    Citation: Molecular Autism 2012 3:12

    Content type: Research

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  35. Reelin regulates neuronal positioning in cortical brain structures and neuronal migration via binding to the lipoprotein receptors Vldlr and Lrp8. Reeler mutant mice display severe brain morphological defects ...

    Authors: Keiko Iwata, Nobuo Izumo, Hideo Matsuzaki, Takayuki Manabe, Yukiko Ishibashi, Yukio Ichitani, Kazuo Yamada, Ismail Thanseem, Ayyappan Anitha, Mahesh Mundalil Vasu, Chie Shimmura, Tomoyasu Wakuda, Yosuke Kameno, Taro Takahashi, Yasuhide Iwata, Katsuaki Suzuki…

    Citation: Molecular Autism 2012 3:11

    Content type: Research

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  36. Autism spectrum disorders (ASD) are early onset neurodevelopmental syndromes typified by impairments in reciprocal social interaction and communication, accompanied by restricted and repetitive behaviors. Whil...

    Authors: Lambertus Klei, Stephan J Sanders, Michael T Murtha, Vanessa Hus, Jennifer K Lowe, A Jeremy Willsey, Daniel Moreno-De-Luca, Timothy W Yu, Eric Fombonne, Daniel Geschwind, Dorothy E Grice, David H Ledbetter, Catherine Lord, Shrikant M Mane, Christa Lese Martin, Donna M Martin…

    Citation: Molecular Autism 2012 3:9

    Content type: Research

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  37. Autism spectrum disorder (ASD) is highly heritable, but the genetic risk factors for it remain largely unknown. Although structural variants with large effect sizes may explain up to 15% ASD, genome-wide assoc...

    Authors: Karyn Meltz Steinberg, Dhanya Ramachandran, Viren C Patel, Amol C Shetty, David J Cutler and Michael E Zwick

    Citation: Molecular Autism 2012 3:8

    Content type: Research

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  38. Social motivation theory suggests that deficits in social reward processing underlie social impairments in autism spectrum disorders (ASD). However, the extent to which abnormalities in reward processing gener...

    Authors: Sonja Delmonte, Joshua H Balsters, Jane McGrath, Jacqueline Fitzgerald, Sean Brennan, Andrew J Fagan and Louise Gallagher

    Citation: Molecular Autism 2012 3:7

    Content type: Research

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  39. Autism spectrum conditions have a strong genetic component. Atypical sensory sensitivities are one of the core but neglected features of autism spectrum conditions. GABRB3 is a well-characterised candidate gene f...

    Authors: Teresa Tavassoli, Bonnie Auyeung, Laura C Murphy, Simon Baron-Cohen and Bhismadev Chakrabarti

    Citation: Molecular Autism 2012 3:6

    Content type: Short report

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  40. Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability (ID), as well as the most frequent monogenic cause of autism spectrum disorder (ASD). Men with FXS exhibit ID, often assoc...

    Authors: Pauline Chaste, Catalina Betancur, Marion Gérard-Blanluet, Anne Bargiacchi, Suzanne Kuzbari, Séverine Drunat, Marion Leboyer, Thomas Bourgeron and Richard Delorme

    Citation: Molecular Autism 2012 3:5

    Content type: Research

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  41. Autism spectrum disorder is a severe early onset neurodevelopmental disorder with high heritability but significant heterogeneity. Traditional genome-wide approaches to test for an association of common varian...

    Authors: Lea K Davis, Eric R Gamazon, Emily Kistner-Griffin, Judith A Badner, Chunyu Liu, Edwin H Cook, James S Sutcliffe and Nancy J Cox

    Citation: Molecular Autism 2012 3:3

    Content type: Research

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  42. Autism spectrum disorders (ASD) represent a group of neurodevelopmental disorders characterized by a core set of social-communicative and behavioral impairments. Gamma-aminobutyric acid (GABA) is the major inh...

    Authors: Dale J Hedges, Kara L Hamilton-Nelson, Stephanie J Sacharow, Laura Nations, Gary W Beecham, Zhanna M Kozhekbaeva, Brittany L Butler, Holly N Cukier, Patrice L Whitehead, Deqiong Ma, James M Jaworski, Lubov Nathanson, Joycelyn M Lee, Stephen L Hauser, Jorge R Oksenberg, Michael L Cuccaro…

    Citation: Molecular Autism 2012 3:2

    Content type: Research

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  43. There is interest in defining mouse neurobiological phenotypes useful for studying autism spectrum disorders (ASD) in both forward and reverse genetic approaches. A recurrent focus has been on high-order behav...

    Authors: Joseph D Buxbaum, Catalina Betancur, Ozlem Bozdagi, Nate P Dorr, Gregory A Elder and Patrick R Hof

    Citation: Molecular Autism 2012 3:1

    Content type: Short report

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