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  1. Autism spectrum disorders (ASDs) are more prevalent in males, suggesting a multiple threshold liability model in which females are, on average, protected by sex-differential mechanisms. Under this model, autis...

    Authors: Donna M Werling and Daniel H Geschwind

    Citation: Molecular Autism 2015 6:27

    Content type: Research

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  2. A 4:1 male to female sex bias has consistently been observed in autism spectrum disorder (ASD). Epidemiological and genetic studies suggest a female protective effect (FPE) may account for part of this bias; h...

    Authors: Jake Gockley, A Jeremy Willsey, Shan Dong, Joseph D Dougherty, John N Constantino and Stephan J Sanders

    Citation: Molecular Autism 2015 6:25

    Content type: Research

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  3. Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant impairment in reciprocal social interactions and communication coupled with stereotyped, repetitive behaviors and r...

    Authors: Valerie W Hu, Tewarit Sarachana, Rachel M Sherrard and Kristen M Kocher

    Citation: Molecular Autism 2015 6:7

    Content type: Research

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  4. SHANK proteins are crucial for the formation and plasticity of excitatory synapses. Although mutations in all three SHANK genes are associated with autism spectrum disorder (ASD), SHANK3 appears to be the major A...

    Authors: Daniela M Cochoy, Alexander Kolevzon, Yuji Kajiwara, Michael Schoen, Maria Pascual-Lucas, Stacey Lurie, Joseph D Buxbaum, Tobias M Boeckers and Michael J Schmeisser

    Citation: Molecular Autism 2015 6:23

    Content type: Research

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  5. Difficulties in recognizing emotions and mental states are central characteristics of autism spectrum conditions (ASC). However, emotion recognition (ER) studies have focused mostly on recognition of the six ‘...

    Authors: Ofer Golan, Yana Sinai-Gavrilov and Simon Baron-Cohen

    Citation: Molecular Autism 2015 6:22

    Content type: Research

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  6. Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with high heritability. Recent findings support a highly heterogeneous and complex genetic etiology including rare de novo and inherited...

    Authors: Marta Codina-Solà, Benjamín Rodríguez-Santiago, Aïda Homs, Javier Santoyo, Maria Rigau, Gemma Aznar-Laín, Miguel del Campo, Blanca Gener, Elisabeth Gabau, María Pilar Botella, Armand Gutiérrez-Arumí, Guillermo Antiñolo, Luis Alberto Pérez-Jurado and Ivon Cuscó

    Citation: Molecular Autism 2015 6:21

    Content type: Research

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  7. Apparently balanced chromosomal rearrangements can be associated with an abnormal phenotype, including intellectual disability and autism spectrum disorder (ASD). Genome-wide microarrays reveal cryptic genomic...

    Authors: Anne-Claude Tabet, Alain Verloes, Marion Pilorge, Elsa Delaby, Richard Delorme, Gudrun Nygren, Françoise Devillard, Marion Gérard, Sandrine Passemard, Delphine Héron, Jean-Pierre Siffroi, Aurelia Jacquette, Andrée Delahaye, Laurence Perrin, Céline Dupont, Azzedine Aboura…

    Citation: Molecular Autism 2015 6:19

    Content type: Research

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  8. Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting more than 1% of children. It is characterized by social communication deficits and repetitive behaviors/restricted interests. In the ab...

    Authors: Deepali Mankad, Annie Dupuis, Sharon Smile, Wendy Roberts, Jessica Brian, Toni Lui, Lisa Genore, Dina Zaghloul, Alana Iaboni, Peggy Margaret A Marcon and Evdokia Anagnostou

    Citation: Molecular Autism 2015 6:18

    Content type: Research

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  9. Autism spectrum disorder (ASD) has a complex genetic etiology. Some symptoms and mutated genes, including neuroligin (NLGN), neurexin (NRXN), and SH3 and multiple ankyrin repeat domains protein (SHANK), are share...

    Authors: Eriko Fujita-Jimbo, Yuko Tanabe, Zhiling Yu, Karin Kojima, Masato Mori, Hong Li, Sadahiko Iwamoto, Takanori Yamagata, Mariko Y Momoi and Takashi Momoi

    Citation: Molecular Autism 2015 6:17

    Content type: Research

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  10. The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals w...

    Authors: Brittany G Travers, Do P M Tromp, Nagesh Adluru, Nicholas Lange, Dan Destiche, Chad Ennis, Jared A Nielsen, Alyson L Froehlich, Molly B D Prigge, P Thomas Fletcher, Jeffrey S Anderson, Brandon A Zielinski, Erin D Bigler, Janet E Lainhart and Andrew L Alexander

    Citation: Molecular Autism 2015 6:15

    Content type: Research

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  11. The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN).

    Authors: Søren Nielsen, Henrik Anckarsäter, Carina Gillberg, Christopher Gillberg, Maria Råstam and Elisabet Wentz

    Citation: Molecular Autism 2015 6:14

    Content type: Research

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  12. An important minority of school-aged autistic children, often characterized as ‘nonverbal’ or ‘minimally verbal,’ displays little or no spoken language. These children are at risk of being judged ‘low-function...

    Authors: Valérie Courchesne, Andrée-Anne S Meilleur, Marie-Pier Poulin-Lord, Michelle Dawson and Isabelle Soulières

    Citation: Molecular Autism 2015 6:12

    Content type: Research

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  13. Preschoolers with autism spectrum disorder (ASD) exhibit difficulties in handling social stress and utilizing efficient emotion regulation (ER) strategies to manage high arousal. While researchers called to as...

    Authors: Sharon Ostfeld-Etzion, Ofer Golan, Yael Hirschler-Guttenberg, Orna Zagoory-Sharon and Ruth Feldman

    Citation: Molecular Autism 2015 6:11

    Content type: Research

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  14. Our laboratory recently characterized a novel autism spectrum disorder (ASD)-associated de novo missense mutation in the human dopamine transporter (hDAT) gene SLC6A3 (hDAT T356M). This hDAT variant exhibits dysf...

    Authors: Peter J Hamilton, Aparna Shekar, Andrea N Belovich, Nicole Bibus Christianson, Nicholas G Campbell, James S Sutcliffe, Aurelio Galli, Heinrich JG Matthies and Kevin Erreger

    Citation: Molecular Autism 2015 6:8

    Content type: Letter to the Editor

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  15. The aim of this study was to investigate potential differences in neural structure in individuals with Asperger syndrome (AS), high-functioning individuals with autism spectrum disorder (ASD). The main symptom...

    Authors: Ulrika Roine, Juha Salmi, Timo Roine, Taina Nieminen-von Wendt, Sami Leppämäki, Pertti Rintahaka, Pekka Tani, Alexander Leemans and Mikko Sams

    Citation: Molecular Autism 2015 6:4

    Content type: Research

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  16. Insufficient vitamin D activity has attracted increasing interest as a possible underlying risk factor in disorders of the central nervous system, including autism.

    Authors: Elisabeth Fernell, Susanne Bejerot, Joakim Westerlund, Carmela Miniscalco, Henry Simila, Darryl Eyles, Christopher Gillberg and Mats B Humble

    Citation: Molecular Autism 2015 6:3

    Content type: Research

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  17. The Autism-Spectrum Quotient (AQ) is a self-report measure of autistic traits. It is frequently cited in diverse fields and has been administered to adults of at least average intelligence with autism and to n...

    Authors: Emily Ruzich, Carrie Allison, Paula Smith, Peter Watson, Bonnie Auyeung, Howard Ring and Simon Baron-Cohen

    Citation: Molecular Autism 2015 6:2

    Content type: Review

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    The Erratum to this article has been published in Molecular Autism 2015 6:45

  18. This study was designed to test a new approach to drug treatment of autism spectrum disorders (ASDs) in the Fragile X (Fmr1) knockout mouse model.

    Authors: Jane C Naviaux, Lin Wang, Kefeng Li, A Taylor Bright, William A Alaynick, Kenneth R Williams, Susan B Powell and Robert K Naviaux

    Citation: Molecular Autism 2015 6:1

    Content type: Research

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  19. There is converging preclinical and clinical evidence to suggest that the extracellular signal-regulated kinase (ERK) signaling pathway may be dysregulated in autism spectrum disorders.

    Authors: Alireza Faridar, Dorothy Jones-Davis, Eric Rider, Jiang Li, Ilan Gobius, Laura Morcom, Linda J Richards, Saunak Sen and Elliott H Sherr

    Citation: Molecular Autism 2014 5:57

    Content type: Research

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  20. There may be a link between anorexia nervosa and autism spectrum disorders. The aims of this study were to examine whether adolescents with anorexia nervosa have autism spectrum and/or obsessive-compulsive tra...

    Authors: Charlotte Rhind, Elena Bonfioli, Rebecca Hibbs, Elizabeth Goddard, Pamela Macdonald, Simon Gowers, Ulrike Schmidt, Kate Tchanturia, Nadia Micali and Janet Treasure

    Citation: Molecular Autism 2014 5:56

    Content type: Research

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  21. Autistic-like traits (ALTs) are continuously distributed in the general population, with the autism spectrum disorder (ASD) at the upper extreme end. A genetic overlap has been shown between ALTs and ASD, indi...

    Authors: Lina Jonsson, Anna Zettergren, Erik Pettersson, Daniel Hovey, Henrik Anckarsäter, Lars Westberg, Paul Lichtenstein, Sebastian Lundström and Jonas Melke

    Citation: Molecular Autism 2014 5:55

    Content type: Short report

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  22. Autism spectrum disorder (ASD) is now understood to have multiple genetic risk genes and one example is SHANK3. SHANK3 deletions and mutations disrupt synaptic function and result in Phelan-McDermid syndrome (PMS...

    Authors: Alexander Kolevzon, Lauren Bush, A Ting Wang, Danielle Halpern, Yitzchak Frank, David Grodberg, Robert Rapaport, Teresa Tavassoli, William Chaplin, Latha Soorya and Joseph D Buxbaum

    Citation: Molecular Autism 2014 5:54

    Content type: Research

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    The Erratum to this article has been published in Molecular Autism 2015 6:31

  23. People with autism spectrum conditions (ASC) report heightened olfaction. Previous sensory experiments in people with ASC have reported hypersensitivity across visual, tactile, and auditory domains, but not ol...

    Authors: Chris Ashwin, Emma Chapman, Jessica Howells, Danielle Rhydderch, Ian Walker and Simon Baron-Cohen

    Citation: Molecular Autism 2014 5:53

    Content type: Research

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  24. Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and interaction, and restrictive and repetitive patterns of behavior, interests or activities. This study aimed to...

    Authors: Wei-Zhen Zhou, Adam Yongxin Ye, Zhong-Kai Sun, Hope Huiping Tian, Tad Zhengzhang Pu, Yu-Yu Wu, Dan-Dan Wang, Ming-Zhen Zhao, Shu-Juan Lu, Chang-Hong Yang and Liping Wei

    Citation: Molecular Autism 2014 5:52

    Content type: Research

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  25. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social cognition. The biological basis of deficits in social cognition in ASD, and their difficulty in processing...

    Authors: Rachel C Leung, Annette X Ye, Simeon M Wong, Margot J Taylor and Sam M Doesburg

    Citation: Molecular Autism 2014 5:51

    Content type: Research

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  26. The ability to interpret agents’ intent from their actions is a vital skill in successful social interaction. However, individuals with autism spectrum disorders (ASD) have been found to have difficulty in att...

    Authors: Lauren E Libero, Jose O Maximo, Hrishikesh D Deshpande, Laura G Klinger, Mark R Klinger and Rajesh K Kana

    Citation: Molecular Autism 2014 5:50

    Content type: Research

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  27. Histone H3 methylation at lysine 9 (H3K9) is a conserved epigenetic signal, mediating heterochromatin formation by trimethylation, and transcriptional silencing by dimethylation. Defective GLP (Ehmt1) and G9a (Eh...

    Authors: Shabeesh Balan, Yoshimi Iwayama, Motoko Maekawa, Tomoko Toyota, Tetsuo Ohnishi, Manabu Toyoshima, Chie Shimamoto, Kayoko Esaki, Kazuo Yamada, Yasuhide Iwata, Katsuaki Suzuki, Masayuki Ide, Motonori Ota, Satoshi Fukuchi, Masatsugu Tsujii, Norio Mori…

    Citation: Molecular Autism 2014 5:49

    Content type: Research

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  28. Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction, alongside unusually repetitive behaviors and narrow interests...

    Authors: Agnese Di Napoli, Varun Warrier, Simon Baron-Cohen and Bhismadev Chakrabarti

    Citation: Molecular Autism 2014 5:48

    Content type: Research

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  29. Individuals with autism spectrum disorder (ASD) show atypical scan paths during social interaction and when viewing faces, and recent evidence suggests that they also show abnormal saccadic eye movement dynami...

    Authors: Lauren M Schmitt, Edwin H Cook, John A Sweeney and Matthew W Mosconi

    Citation: Molecular Autism 2014 5:47

    Content type: Research

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  30. Autism spectrum disorders (ASD) are much more common in males than in females. Molecular alterations within the estrogen receptor (ER) signaling pathway may contribute to the sex difference in ASD, but the ext...

    Authors: Amanda Crider, Roshni Thakkar, Anthony O Ahmed and Anilkumar Pillai

    Citation: Molecular Autism 2014 5:46

    Content type: Research

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  31. Although the neurobiological basis of autism spectrum disorder (ASD) is not fully understood, recent studies have indicated the potential role of GABAA receptors in the pathophysiology of ASD. GABAA receptors pla...

    Authors: Amanda Crider, Chirayu D Pandya, Diya Peter, Anthony O Ahmed and Anilkumar Pillai

    Citation: Molecular Autism 2014 5:45

    Content type: Research

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  32. Duplications of the chromosome 15q11-q13.1 region are associated with an estimated 1 to 3% of all autism cases, making this copy number variation (CNV) one of the most frequent chromosome abnormalities associa...

    Authors: Noelle D Germain, Pin-Fang Chen, Alex M Plocik, Heather Glatt-Deeley, Judith Brown, James J Fink, Kaitlyn A Bolduc, Tiwanna M Robinson, Eric S Levine, Lawrence T Reiter, Brenton R Graveley, Marc Lalande and Stormy J Chamberlain

    Citation: Molecular Autism 2014 5:44

    Content type: Research

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  33. Patients with autism spectrum disorder (ASD) may have low brain serotonin concentrations as reflected by the serotonin end-metabolite 5-hydroxyindolacetic acid (5HIAA) in cerebrospinal fluid (CSF).

    Authors: Dea Adamsen, Vincent Ramaekers, Horace TB Ho, Corinne Britschgi, Véronique Rüfenacht, David Meili, Elise Bobrowski, Paule Philippe, Caroline Nava, Lionel Van Maldergem, Rémy Bruggmann, Susanne Walitza, Joanne Wang, Edna Grünblatt and Beat Thöny

    Citation: Molecular Autism 2014 5:43

    Content type: Research

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  34. Empathy is a vital component for social understanding involving the ability to recognise emotion (cognitive empathy) and provide an appropriate affective response (emotional empathy). Autism spectrum condition...

    Authors: Rachel Grove, Andrew Baillie, Carrie Allison, Simon Baron-Cohen and Rosa A Hoekstra

    Citation: Molecular Autism 2014 5:42

    Content type: Research

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  35. Autism is a neurodevelopmental disorder characterized by impaired language, communication and social skills. Although genetic studies have been carried out in this field, none of the genes identified have led ...

    Authors: Jantine AC Broek, Paul C Guest, Hassan Rahmoune and Sabine Bahn

    Citation: Molecular Autism 2014 5:41

    Content type: Research

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  36. As regulators of gene expression, microRNAs (miRNAs) play a key role in the transcriptional networks of the developing human brain. Circulating miRNAs in the serum and plasma are remarkably stable and are sugg...

    Authors: Mahesh Mundalil Vasu, Ayyappan Anitha, Ismail Thanseem, Katsuaki Suzuki, Kohei Yamada, Taro Takahashi, Tomoyasu Wakuda, Keiko Iwata, Masatsugu Tsujii, Toshirou Sugiyama and Norio Mori

    Citation: Molecular Autism 2014 5:40

    Content type: Research

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  37. Over the last decade, the transgenic N-methyl-D-aspartate receptor (NMDAR) NR1-knockdown mouse (NR1neo−/−) has been investigated as a glutamate hypofunction model for schizophrenia. Recent research has now reveal...

    Authors: Hendrik Wesseling, Paul C Guest, Chi-Ming Lee, Erik HF Wong, Hassan Rahmoune and Sabine Bahn

    Citation: Molecular Autism 2014 5:38

    Content type: Research

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  38. It is widely accepted that emotion processing difficulties are involved in Autism Spectrum Conditions (ASC). An increasing number of studies have focused on the development of training programs and have shown ...

    Authors: Sylvie Serret, Stephanie Hun, Galina Iakimova, Jose Lozada, Margarita Anastassova, Andreia Santos, Stephanie Vesperini and Florence Askenazy

    Citation: Molecular Autism 2014 5:37

    Content type: Research

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  39. GABRB3 is a position candidate gene at chromosome 15q12 that has been implicated in the neurobiology of autism spectrum disorders (ASD). The aim of this study was to examine the genetic association of GABRB3 with...

    Authors: Chia-Hsiang Chen, Chia-Chun Huang, Min-Chih Cheng, Yen-Nan Chiu, Wen-Che Tsai, Yu-Yu Wu, Shih-Kai Liu and Susan Shur-Fen Gau

    Citation: Molecular Autism 2014 5:36

    Content type: Research

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  40. Autism spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development (TD). Social cognition properties that are deeply associated wi...

    Authors: Minyoung Jung, Hirotaka Kosaka, Daisuke N Saito, Makoto Ishitobi, Tomoyo Morita, Keisuke Inohara, Mizuki Asano, Sumiyoshi Arai, Toshio Munesue, Akemi Tomoda, Yuji Wada, Norihiro Sadato, Hidehiko Okazawa and Tetsuya Iidaka

    Citation: Molecular Autism 2014 5:35

    Content type: Research

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  41. There is an urgent need for expanding and enhancing autism spectrum disorder (ASD) samples, in order to better understand causes of ASD.

    Authors: Joseph D Buxbaum, Nadia Bolshakova, Jessica M Brownfeld, Richard JL Anney, Patrick Bender, Raphael Bernier, Edwin H Cook, Hilary Coon, Michael Cuccaro, Christine M Freitag, Joachim Hallmayer, Daniel Geschwind, Sabine M Klauck, John I Nurnberger, Guiomar Oliveira, Dalila Pinto…

    Citation: Molecular Autism 2014 5:34

    Content type: Research

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  42. Changes in serotonin transporter (SERT) function have been implicated in autism. SERT function is influenced by the number of transporter molecules present at the cell surface, which is regulated by various ce...

    Authors: Keiko Iwata, Hideo Matsuzaki, Taro Tachibana, Koji Ohno, Saori Yoshimura, Hironori Takamura, Kohei Yamada, Shinsuke Matsuzaki, Kazuhiko Nakamura, Kenji J Tsuchiya, Kaori Matsumoto, Masatsugu Tsujii, Toshirou Sugiyama, Taiichi Katayama and Norio Mori

    Citation: Molecular Autism 2014 5:33

    Content type: Research

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  43. As elegant structures designed for neural communication, synapses are the building bricks of our mental functions. Recently, many studies have pointed out that synaptic protein-associated mutations may lead to...

    Authors: Li-Feng Jiang-Xie, Hsiao-Mei Liao, Chia-Hsiang Chen, Yuh-Tarng Chen, Shih-Yin Ho, Dai-Hua Lu, Li-Jen Lee, Horng-Huei Liou, Wen-Mei Fu and Susan Shur-Fen Gau

    Citation: Molecular Autism 2014 5:32

    Content type: Research

    Published on:

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