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Fig. 7 | Molecular Autism

Fig. 7

From: The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome

Fig. 7

VU 0155041 ameliorates VOR and social interaction deficits of Fmr1KO mice. a Experimental design. Table rotations (red) and eye positions (green). Examples of eye movements. b VOR gain. 0.1 Hz: WT sal (n = 10), Fmr1KO sal (n = 10), *P < 0.05, WT VU (n = 11), P > 0.05 and Fmr1KO VU (n = 11), P > 0.05, compared to WT sal. Fmr1KO VU vs Fmr1KO sal, P > 0.05 (Kruskal–Wallis followed by Dunn’s test). c VOR phase. 0.6 Hz: Fmr1KO sal, *P < 0.05, WT VU, P > 0.05, Fmr1KO VU, P > 0.05, compared to WT sal. Fmr1KO VU versus Fmr1KO sal, P > 0.05 (one-way ANOVA followed by Holm-Sidak’s test). d Fast phases per vestibuloocular cycle. 0.6 Hz: Fmr1KO sal, *P < 0.05, WT VU, P > 0.05 and Fmr1KO VU, P > 0.05, compared to WT sal. Fmr1KO VU vs Fmr1KO sal, *P < 0.05 (one-way ANOVA followed by Holm-Sidak’s test). 0.3 Hz: Fmr1KO sal, *P < 0.05, WT VU, P > 0.05, Fmr1KO VU, P > 0.05, compared to WT sal. Fmr1KO VU compared to Fmr1KO sal, **P < 0.01 (one-way ANOVA followed by Holm-Sidak’s test). e Relation between VOR gain and fast phases frequency. 0.6 Hz: Fmr1KO sal, *P < 0.05, WT VU, P > 0.05, Fmr1KO VU, P > 0.05, compared to WT sal. Fmr1KO VU vs Fmr1KO sal, *P < 0.05 (Kruskal–Wallis followed by Dunn’s test). 0.3 Hz: Fmr1KO sal, **P < 0.01, WT VU, P > 0.05, Fmr1KO VU, P > 0.05, compared to WT sal. Fmr1KO VU versus Fmr1KO sal, *P < 0.05 (Kruskal–Wallis followed by Dunn’s test). f Sociability test set-up. g Discrimination Index between mouse-containing and empty cages is measured and compared to the WT sal (n = 31): Fmr1KO sal (n = 30, **P = 0.0047); WT VU (n = 31, P = 0.8410); (Fmr1KO VU (n = 32, P = 0.9321). (**P = 0.0064, Fmr1KO VU compared to Fmr1KO WT sal). h Social novelty test set-up. i Discrimination Index between unfamiliar and familiar mice is measured and compared to WT sal (n = 31): Fmr1 KO sal (n = 30, ***P < 0.0004); WT VU (n = 31, P = 0.2219); Fmr1 KO VU (n = 32, P > 0.1959). (*P = 0.0185, Fmr1KO VU compared to Fmr1KO WT sal). Two-way ANOVA followed by LSD’s test (g, i). Bar graphs show raw data and the mean. n is the number of mice used

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Molecular Autism

ISSN: 2040-2392