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Fig. 2 | Molecular Autism

Fig. 2

From: The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome

Fig. 2

An increased aEPSC frequency and absence of isoproterenol induced potentiation at Fmr1KO synapses. a Isoproterenol (100 μM, 10 min) enhances the sEPSCs recorded in the presence of Sr2+ (2.5 mM) in WT but not in Fmr1KO slices. b Quantification of the effects of isoproterenol on the sEPSC amplitude in WT (n = 9, ***P < 0.001 compared to control values) and in Fmr1KO slices (n = 6, P > 0.05). c Individual traces showing asynchronous release events in control (black) and isoproterenol exposed (red) WT and Fmr1KO slices. d, f Quantification of the isoproterenol induced changes in aEPSC frequency (d) in WT (n = 306 events/9 slices and, n = 502 events/9 slices: ***P < 0.001) and Fmr1KO slices (n = 305 events/6 and n = 312 events/6 slices: P > 0.05 comparing to control values; #P < 0.05 comparing to control aEPSC frequency in WT slices), as well as in amplitude (f) in WT (P > 0.05) and in Fmr1KO slices (P > 0.05). e, g Cumulative probability plots of isoproterenol induced changes in aEPSC frequency (inter event interval, IEI) (e) in WT (***P < 0.001) and Fmr1KO slices (P > 0.05), and amplitude (g) in WT (P > 0.05) and Fmr1KO slices (P > 0.05). Bar graphs show raw data and the mean. Scale bars in (a, c) represent 100 pA and 10 ms, and 25 pA and 10 ms, respectively. Two-way ANOVA followed by Tukey test in (b, d, f). Kolmogorov–Smirnov test in (e, g). Several slices per mice were prepared

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