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Table 2 Overview of analytical strategy and key results

From: CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions

Goal(s) and domains targeted

Main Analytic methods

Findings

Assessment of the pandemic impact on changes of the AFAR-based symptom ratings (i.e., Adaptive living skills, lower-order RRB, higher-order RRB, activity/inattention, oppositional, anxiety/affect, sleep problems) and services (lost or modified at and outside school)

[Table 1, Additional file 1: Table S6]

Pandemic outcome subgroups identification and characterization

Hierarchical clustering

Four outcome subgroups with differing profiles of change relative to the aggregate’s average change:

 -Broad symptom worsening only (20%)

 -Primarily modified services (23%)

 -Primarily lost services (6%)

 -Average symptom/service changes (53%)

[Figs. 4 and 5, Additional file 1: Table S7, Fig. S3]

Whole (aggregate) sample main effects analyses

One-way repeated measures MANCOVA (within-subject factor time; covariate: contributing sample); Post hoc one-way repeated measures ANCOVA for each symptom factor

Significant effect of time was driven by worsening sleep problems ratings, other symptoms did not reach statistical significance [Fig. 5]

Central tendency descriptive measures

On average, lost 1 service and continued 1 other at and outside school

[Additional file 1: Table S7]

Prediction of outcome subgroup membership across 20 features including pre-pandemic variables (e.g., service at and outside school, child, and family’s characteristics), pandemic-related experiences (e.g., COVID worry) and environment (containment measures)

[Fig. 2, Additional file 1: Table S2, Fig. S4]

Random Forest classification, ranking feature importance indexed by out-of-bag-error (OOBE)

81% classification accuracy. Pre-pandemic services in and outside school, Sringency index, Lifestyle Stress, COVID Worries, new COVID infections and age were top predictors (OOBE 16–1%). Other features had negligible importance (< 1%). Each outcome subgroup had distinct profiles of increases or decreases across the top predictors [Fig. 6, Table 3, Additional file 1: Table S7]