Fig. 2

ASD subtype analysis based on the network-level IDFC. A Mean silhouette plots, indicating that the optimal number of clusters is 2. B The results of k-means clustering shown on the 2-dimensional plane. C Mean IDFC patterns at the network level of two ASD subtypes. Red inner ring represents ASD subjects belonging to subtype 1, and blue inner ring represents ASD subjects belonging to subtype 2. The outer circle indicates the network corresponding to the mean IDFC. D Mean IDFC patterns at the region level of two ASD subtypes. The two inner rings represent the mean IDFC of ROIs, and the outer ring indicates the network corresponding to ROIs. Red inner ring represents ASD subjects belonging to subtype 1, and blue inner ring represents ASD subjects belonging to subtype 2. IDFC, inter-individual deviation of functional connectivity; ASD, autism spectrum disorder; ROI, region of interest; SMN, somatosensory network; CO, cingulo-opercular network; AN, auditory network; DMN, default-mode network; VN, visual network; FPN, fronto-parietal network; SAN, salience network; SUB, subcortical network; VAN, ventral attention network; DAN, dorsal attention network; and UND, uncertain network