Fig. 6
From: Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice
Summary of the results obtained in Western Blot and behavioral analysis. A General summary of all Western Blot results, indicating all the proteins affected in the Sal-KO, Pol-WT and Pol-KO groups, first in the striatum, then the hippocampus and finally in the prefrontal cortex. The effects in both the homogenate and the P3 fraction are displayed. The Sal-KO and Pol-WT groups are compared to the control (Sal-WT), whereas Pol-KO is compared to Sal-KO. B General summary of all behavioral results, indicating deficits in all experimental groups. All groups are compared to the control (Sal-WT) except Pol-KO which is compared to Sal-KO. The dotted lines separate the three sets of experiments, starting from the top—social behavior, repetitive behavior and comorbidities. C Comparison between Sal-KO (Shank3Δ11 − / −) and Pol-KO (two-hit), indicating alterations in postsynaptic proteins and behavior. The Sal-KO group is compared to the control (Sal-WT), whereas Pol-KO is compared to Sal-KO. A–C A red bar indicates an increase, and a blue bar indicates a decrease. The bars are not indicative of the amount of decrease or increase. Only statistically significant results (p < 0.05) are displayed in the figure