Profiles of autism characteristics in thirteen genetic syndromes: a machine learning approach

Table 3 The level of contribution of each SCQ item to the predictions of the SVM model

SCQ characteristics	AS	FXS	PWS	RTS	CdLS	DS	CdCS	1p36	LS	SMS	TSC	SS	PMS	ASD
1. Short phrases						−		+
2. Reciprocal Conversation				+		+		+
3. Odd phrases	+			+		+					+
4. Inappropriate questions		−		+	−	+				−	+	−		−
5. Pronoun reversal				+	−	+		+	−	−	+		+
6. Made up words			−	+		+	−				+
7. Phrase/word repetition											+
8. Repetitive rituals									−	−
9. Inappropriate facial expressions		−									−		−
10. Use others as tools			−	−									−	−
11. Unusual interests			−					−					−
12. Interested in parts of objects			−	−				−			−		−	−
13. Unusually intense interests					−		−						−
14. Unusual interest in smell, taste	+								−			+
15. Odd mannerisms
16. Complicated body movements	+	+	+		+		+		+	+		+	+	+
17. Self−harm			+
18. Carry objects around		−			−			−	−		−
19. Best friend	+		+		+		+							+
20. Friendly conversation		+			+		+	+	+	+		+	+	+
21. Spontaneous imitation						−
22. Spontaneously show interest	−	+		−	−						−	−		−
23. Use gestures						−
24. Nod head for "yes"	−						−
25. Shaked head for "no"		−
26. Face-to-face conversation
27. Smile back	−			−			−				−			−
28. Special interests
29. Share things with others	−									+
30. Invite to join in their enjoyment										−		−
31. Offer comfort		−				−
32. Eye contact		+	+		+		+	+	+	+		+	+	+
33. A range of facial expressions						−		−
34. Spontaneous social play
35. Pretend games
36. Interested in unknown peers										−		−
37. Positive approach to peers
38. Pay attention to one’s voice	−		−	−			−
39. Imaginative play	+	+	+		+		+		+	+		+	+	+
40. Cooperative play								−	+			−

+ reflects the top five items, which contribute the most to the model,—represents the top 5 items, which contribute the least to the model for each syndrome group. These symbols ( ±) do not represent high or low scores on these items, they represent the level of contribution to the classification model
AS Angelman syndrome, CdCS Cri du Chat syndrome, 1p36 1p6 deletion syndrome, CdLS Cornelia de Lange syndrome, FXS fragile X syndrome, PWS Prader–Willi syndrome, LS Lowe syndrome, SMS Smith–Magenis syndrome, DS Down syndrome, SS Sotos syndrome, RTS Rubinstein–Taybi syndrome, TSC Tuberous sclerosis complex, PMS Phelan-McDermid syndrome, ASD Autism spectrum disorder

ISSN: 2040-2392