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Fig. 5 | Molecular Autism

Fig. 5

From: Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

Fig. 5

The stability of CA1 pyramidal cell firing rate maps does not differ between WT and Fmr1−/y rats. A Example firing rate maps from 4 WT (left) and 4 Fmr1−/y (right) CA1 pyramidal cells, each from a different animal. Smoothed firing rate maps of the same cell, with warmer colours indicating higher firing rates. R values from Pearson correlations (Fisher z-transformed) between the firing rate maps of consecutive exploration sessions are indicated below the arrows between sessions. B Mean Pearson correlation coefficients (Fisher z-transformed) between firing rate maps for consecutive sessions for the population of WT and Fmr1−/y pyramidal cells. Firing rate map stability did not differ significantly between WT and Fmr1−/y cells (genotype p = 0.094). Both genotypes had less stable maps between days (Session 3–4 comparison) than between sessions of the same day (post hoc tests on S3-S4 vs all other comparisons, #p’s < 0.05). Data represent cell means and SEM. Statistical analyses used LME modelling with genotype and session comparison (i.e. S1-S2, S2-S3, S3-S4, S4-S5 and S5-S6) as fixed factors, and cell and rat as random factors, followed by Tukey post hoc comparisons on emmeans for significant main effect of session. S1vsS2: NWT = 194, NKO = 167, S2vsS3: NWT = 191, NKO = 179, S3vsS4: NWT = 121, NKO = 152, S4vsS5: NWT = 190, NKO = 161, S5vsS6: NWT = 188, NKO = 169. Pale yellow and pale purple backgrounds denote data from Day 1 and Day 2, respectively

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