Fig. 4
Experience-dependent refinement of spatial coding in the CA1 pyramidal cells is impaired in Fmr1−/y rats. A The spatial information of CA1 pyramidal cells increased between the first and second day of exploration in the novel environment in WT but not in in Fmr1−/y rats, with no significant difference between genotypes on either day (genotype x day interaction p = 0.005; post hoc comparisons Day 1 vs Day 2: WT p < 0.001; Fmr1−/y p = 0. 129; WT vs Fmr1−/y: p > 0.05 on both days). B The spatial sparsity of CA1 pyramidal cell firing decreased significantly between Day 1 and Day 2 in WT but not Fmr1−/y rats, with no differences between genotypes on either day (genotype x day interaction p = 0.013; post hoc comparisons Day 1 vs Day 2: WT p < 0.001; Fmr1−/y p = 0.091; WT vs Fmr1−/y: p > 0.05 on both days). C The size of CA1 pyramidal cell place fields decreased significantly between Day 1 and Day 2 in WT but not Fmr1−/y rats, with no differences between genotypes on either day (genotype x day interaction p = 0.017; post hoc comparisons Day 1 vs Day 2: WT p < 0.001; Fmr1−/y p = 0.051; WT vs Fmr1−/y: p > 0.05 on both days). D The proportion of visited pixels in which CA1 pyramidal cells fired (% active bins) did not differ significantly across days or between genotypes (genotype x day interaction p = 0.070). Data represent cell means and SEMs. Statistical analyses using LME modelling and Tukey post hoc tests as in Fig. 2. NWT-D1 = 222, NWT-D2 = 207, NKO-D1 = 211, NKO-D2 = 205. Pale yellow and pale purple backgrounds denote data from Day 1 and Day 2, respectively