Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children

Table 2 Effects of total sensory features on brainstem FWE-MD in autistic and non-autistic children

Brainstem White Matter Region	Total sensory features main effect				Group x total sensory Features interaction effect
Brainstem White Matter Region	b	Std Error	t	p	b	Std Error	t	p
CST	0.008	0.005	1.51	.13	− 0.026	0.011	− 2.41	.02^a,b
ML	0.004	0.004	1.06	.29	− 0.025	0.008	− 3.07	< .001 ^a,b
LL	− 0.001	0.005	− 0.12	.90	− 0.032	0.011	− 2.93	< .001 ^a,b
FPT	0.007	0.007	0.94	.35	− 0.019	0.014	− 1.31	.19
POTPT	0.004	0.005	0.93	.36	− 0.032	0.010	− 3.25	< .001 ^a,b
STT	0.001	0.004	0.36	.72	− 0.020	0.008	− 2.51	.01 ^a,b
SCPCT	0.004	0.004	1.10	.27	− 0.022	0.008	− 2.77	.01 ^a,b
SCPSC	0.002	0.006	0.33	.74	− 0.011	0.012	− 0.95	.34
ICPMC	− 0.002	0.006	− 0.28	.78	− 0.025	0.012	− 2.14	.03 ^a,b
ICPVC	− 0.002	0.006	− 0.40	.69	− 0.025	0.012	− 2.15	.03 ^a,b
MCP	0.001	0.004	0.20	.85	− 0.020	0.009	− 2.22	.03 ^a,b

Main and interaction effects controlling for age, sex and average head motion during DWI brain scan
ML medial lemniscus; LL lateral lemniscus; STT spinothalamic tract; SCPCT superior cerebellar peduncle cerebellothalamic tract; SCPSC superior cerebellar peduncle spinocerebellar tract; MCP middle cerebellar peduncle; ICPMC inferior cerebellar peduncle tracts from medulla oblongata to the cerebellum; ICPVCT inferior cerebellar peduncle vestibulocerebellar tract; FPT frontopontine tract; POTPT parieto-occipito-temporo-pontine tract; CST corticospinal tract
^aUncorrected p < .05
^bFalse discovery rate (FDR) corrected p < .05

ISSN: 2040-2392