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Table 2 Logistic regression of each outcome on maternal 25(OH)D adjusted for season and 20-week gestation

From: Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study

Outcome

Model

Complete record analysis

Multiple imputation analysis

OR

95% CI

OR

95% CI

Autism diagnosis

Unadjusted

0.99

(0.91, 1.07)

1.00

(0.94, 1.07)

Adjusted 1

0.99

(0.91, 1.07)

1.01

(0.94, 1.07)

Adjusted 2

0.99

(0.91, 1.07)

1.00

(0.94, 1.07)

Adjusted 3

0.98

(0.90, 1.06)

0.99

(0.93, 1.06)

Fully adjusted

0.98

(0.90, 1.06)

0.99

(0.93, 1.06)

Social communication trait

Unadjusted

1.00

(0.97, 1.03)

0.99

(0.97, 1.02)

Adjusted 1

1.00

(0.97, 1.02)

0.99

(0.97, 1.02)

Adjusted 2

1.00

(0.97, 1.03)

0.99

(0.97, 1.02)

Adjusted 3

1.00

(0.97, 1.03)

1.00

(0.98, 1.03)

Fully adjusted

1.00

(0.97, 1.03)

1.00

(0.98, 1.03)

Speech coherence trait

Unadjusted

0.99

(0.96, 1.02)

1.00

(0.98, 1.02)

Adjusted 1

0.99

(0.96, 1.02)

1.00

(0.98, 1.02)

Adjusted 2

0.99

(0.96, 1.02)

1.00

(0.98, 1.03)

Adjusted 3

0.99

(0.96, 1.02)

1.00

(0.98, 1.03)

Fully adjusted

0.99

(0.96, 1.02)

1.00

(0.98, 1.03)

Repetitive behaviour trait

Unadjusted

0.99

(0.96, 1.01)

0.98

(0.96, 1.00)

Adjusted 1

0.98

(0.96, 1.01)

0.98

(0.96, 1.00)

Adjusted 2

0.99

(0.96, 1.01)

0.98

(0.96, 1.00)

Adjusted 3

0.99

(0.96, 1.01)

0.98

(0.96, 1.00)

Fully adjusted

0.99

(0.96, 1.01)

0.98

(0.96, 1.00)

Sociability temperament trait

Unadjusted

1.01

(0.97, 1.04)

0.99

(0.97, 1.02)

Adjusted 1

1.00

(0.97, 1.04)

1.00

(0.97, 1.02)

Adjusted 2

1.01

(0.98, 1.04)

1.00

(0.97, 1.02)

Adjusted 3

1.00

(0.97, 1.04)

1.00

(0.97, 1.02)

Fully adjusted

1.00

(0.97, 1.04)

1.00

(0.97, 1.02)

  1. Odds ratios reflect a 10 nmol/L change in adjusted 25(OH)D
  2. Adjusted 1 = adjusted for offspring sex;
  3. Adjusted 2 = adjusted for financial difficulties, maternal education, and maternal occupational class;
  4. Adjusted 3 = adjusted for parity, maternal age at birth, pre-pregnancy BMI and smoking status during pregnancy;
  5. Fully adjusted = adjusted for all variables in adjusted 1–3
  6. Complete record analysis N = 5013 for autism diagnosis; 3526 for social communication trait; 3394 for speech coherence trait; 3464 for repetitive behaviour trait; 4209 for sociability temperament trait
  7. Multiple imputation analysis N = 7689 for all outcomes