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Table 2 Association between global morphological brain measures and autistic traitsa

From: The longitudinal bidirectional relationship between autistic traits and brain morphology from childhood to adolescence: a population-based cohort study

Brain measures

Model 1

Model 2

ß

SD

t-statistic

p value

ß

SD

t-statistic

p value

Total brain volume

− 0.06

0.88

− 3.16

0.002*

− 0.03

0.88

− 1.69

0.089

Cortical gray matter volume

− 0.06

0.88

− 3.17

0.001*

− 0.03

0.88

− 1.46

0.144

Subcortical gray matter volume

− 0.06

0.88

− 2.79

0.005*

− 0.04

0.88

− 1.77

0.075

Cerebral white matter volume

− 0.04

0.88

− 2.09

0.036

− 0.02

0.88

− 1.12

0.256

CSF volume

− 0.01

0.88

− 0.61

0.540

0.01

0.88

0.54

0.592

Cerebellum cortex volume

− 0.08

0.88

− 4.15

3.39·10–5*

− 0.06

0.88

− 2.84

0.004*

Cerebellum white matter volume

− 0.06

0.88

− 2.92

0.003*

− 0.05

0.88

− 2.34

0.019

Mean amygdala volume (L + R)

− 0.05

0.88

− 2.39

0.017

− 0.02

0.88

− 0.96

0.339

Mean gyrification

− 0.09

0.88

− 4.24

2.25·10–5*

− 0.06

0.88

− 2.81

0.005*

Mean surface area

− 0.09

0.88

− 4.73

2.44·10–6*

− 0.06

0.88

− 3.12

0.002*

Mean cortical thickness

0.03

0.88

1.47

0.142

0.05

0.88

2.38

0.018

  1. aModel 1 is adjusted for sex, age at SRS and the difference in age between SRS and MRI; Model 2 is additionally adjusted for child ethnicity, maternal education, maternal smoking and drinking during pregnancy. The effects are standardized
  2. *Significant after Bonferroni correction (p < 0.005)