Fig. 3

Reactivity to eye opening: distribution and age trends in the training (A) and the validation dataset (B). The scatter plot of the raw values as a function of age is shown in the left side, along with the regression lines for each group. The distribution of reactivity values for each age group along with the corresponding Cohen’s d effect size is shown on the right side. Typically, d ~ 0.20 is considered small and d ~ 0.50 a medium effect size. PI indicates the 95% prediction interval from the training dataset to the validation dataset, and it was calculated following [38] based on the training dataset effects and the sample size of both datasets