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Fig. 12 | Molecular Autism

Fig. 12

From: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice

Fig. 12

Effects of Myt1l haploinsufficiency on fear conditioning. A–C Fear-related freezing behavior is enhanced in male and female Myt1l+/- mice during acquisition on the training day. Gray highlighting indicates tone presentations (1 min inter-stimulus intervals). Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T), followed by unpaired t tests when appropriate. T: F12,624 = 190.370; p < .001; TxG: F12,624 = 3.535; p < .001; TxS: F12,624 = 2.355; p = .006; TxGxS: F12,624 = 2.015; p = .021; G: F1,52 = 4.803; p = .033; S: F1,52 = 25.623; p < .001; all other p > 0.050. D–F Fear-related freezing behavior is enhanced in male but not female Myt1l+/- mice during contextual recall. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T), followed by unpaired t tests when appropriate. T: F9,468 = 23.286; p < .001; TxG: F9,468 = 2.660; p = .005; G: F1,52 = 6.682; p = .013; S: F1,52 = 16.678; p < .001; all other p > 0.050. All data are means ± SEM, combined across males and females if not otherwise indicated; *p < 0.05; **p < 0.01; ***p < 0.001

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