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Table 2 Demographic and clinical profiles across subgroups

From: Two neuroanatomical subtypes of males with autism spectrum disorder revealed using semi-supervised machine learning

  Subtype 1 (n = 115) Subtype 2 (n = 106) HC (n = 257) p value a p value b p value c
Age 15.3 ± 6.8 15.5 ± 6.0 14.2 ± 6.1 0.825 0.104 0.056
Type (A/AS/P/NA) 58/11/5/41 58/12/4/32 0.926
IQ
 FIQ 111 ± 15.3 104 ± 13.5 114 ± 12.1  < 0.001 0.182  < 0.001
 VIQ 109 ± 15.7 107 ± 16.1 114 ± 13.0 0.545 0.006 0.001
 PIQ 112 ± 14.3 103 ± 13.7 111 ± 13.0  < 0.001 0.714  < 0.001
Site 14/17/21/10/10/18/25 11/11/14/10/12/20/28 22/66/41/21/25/35/47 0.791
ADOS
 Total 11.8 ± 3.6 10.7 ± 3.3 1.3 ± 1.7 0.041  < 0.001  < 0.001
 Comm 3.7 ± 1.6 3.5 ± 1.3 0.6 ± 1.0 0.469  < 0.001  < 0.001
 Social 8.1 ± 2.5 7.4 ± 2.6 0.7 ± 1.0 0.111  < 0.001  < 0.001
 RRB 2.1 ± 1.8 1.7 ± 1.5 0.1 ± 0.5 0.090  < 0.001  < 0.001
 Severity 7.7 ± 1.5 6.4 ± 2.4 0.004
ADI-R
 Social 20.5 ± 5.0 19.5 ± 5.2 0.209
 Verbal 16.3 ± 4.3 15.4 ± 4.6 0.219
 RRB 6.1 ± 2.5 6.4 ± 2.5 0.517
SRS
 Total 96.1 ± 32.8 90.5 ± 32.0 17.7 ± 12.9 0.342  < 0.001  < 0.001
 Aware 13.2 ± 4.0 11.7 ± 3.4 4.3 ± 2.7 0.096  < 0.001  < 0.001
 Cognit 16.6 ± 6.2 14.9 ± 5.8 2.8 ± 2.7 0.223  < 0.001  < 0.001
 Comm 33.8 ± 10.1 28.9 ± 11.8 5.7 ± 5.1 0.058  < 0.001  < 0.001
 Motiva 15.5 ± 5.8 12.9 ± 7.3 3.7 ± 3.1 0.095  < 0.001  < 0.001
 Manner 18.9 ± 6.3 17.3 ± 7.1 1.9 ± 2.5 0.316  < 0.001  < 0.001
  1. The p values were calculated using a two-sample t test except for the type and site composition (aSubtype1 vs. Subtype2; bHC vs. Subtype1; cHC vs. Subtype2). Abbreviations: IQ, intelligence quotient; FIQ, full-scale IQ; VIQ, verbal IQ; PIQ, performance IQ; ADOS, autism diagnostic observation schedule; Social, social interaction; Comm, communication. RRB, restricted repetitive behavior. ADOS Total = social interaction + communication; ADI-R, autism diagnostic interview revised; SRS, Social Responsiveness Scale; Aware, awareness; Cognit, cognition; Motiva, motivation; Manner, mannerisms; The number of ASD patients with IQ, ADOS scores, ADI-R scores, and SRS scores available are described in the Supplement Table S2