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Table 1 Demographic and clinical data

From: Two neuroanatomical subtypes of males with autism spectrum disorder revealed using semi-supervised machine learning

 

Site 1 (GU)

Site 2 (KKI)

Site 3 (OHSU)

Site 4 (PITT)

Site 5 (TRINITY)

Site 6 (UCLA)

Site 7 (USM)

 

HC

ASD

HC

ASD

HC

ASD

HC

ASD

HC

ASD

HC

ASD

HC

ASD

N

22

25

66

28

41

35

21

20

25

22

35

38

44

53

Type (A/AS/P/NA)

–

0/0/0/25

–

11/16/1/0

–

0/0/0/35

–

20/0/0/0

–

8/7/7/0

–

32/0/0/6

–

45/0/1/7

Age

10.8 ± 1.7

11.1 ± 1.7

10.5 ± 1.3

10.3 ± 1.6

10.3 ± 1.5

11.7 ± 2.1

19.3 ± 7.1

19.9 ± 7.2

17.1 ± 3.8

17.1 ± 3.6

12.8 ± 2.3

13.0 ± 2.3

21.6 ± 7.5

22.1 ± 7.1

IQ

 FIQ

121 ± 12.0

121 ± 12.9

114 ± 11.2

106 ± 14.1

114 ± 13.1

109 ± 15.5

110 ± 9.1

113 ± 14.1

111 ± 12.2

110 ± 13.1

107 ± 11.2

103 ± 11.4

115 ± 13.3

104 ± 15.1

 VIQ

122 ± 13.0

123 ± 11.5

119 ± 11.0

113 ± 15.0

–

–

108 ± 10.3

110 ± 13.0

110 ± 13.7

109 ± 14.0

109 ± 11.3

105 ± 13.2

113 ± 13.5

100 ± 16.1

 PIQ

117 ± 15.0

117 ± 14.2

113 ± 12.9

107 ± 15.0

–

–

108 ± 10.0

112 ± 14.3

110 ± 9.1

110 ± 10.9

104 ± 12.3

101 ± 13.2

114 ± 13.3

107 ± 14.9

ADOS

 Total

–

10.3 ± 5.0

–

10.6 ± 1.8

–

9.0 ± 3.3

–

12.0 ± 3.1

–

10.3 ± 2.9

–

11.1 ± 3.7

–

12.5 ± 3.1

 Comm

–

2.9 ± 1.7

–

3.2 ± 0.6

–

2.8 ± 1.3

–

4.1 ± 1.0

–

–

–

3.3 ± 1.5

–

4.3 ± 1.4

 Social

–

7.4 ± 3.8

–

7.4 ± 1.5

–

6.2 ± 2.2

–

8.0 ± 2.4

–

–

–

7.8 ± 2.7

–

8.2 ± 2.3

 RRB

–

1.6 ± 1.6

–

2.8 ± 1.6

–

2.1 ± 1.1

–

2.5 ± 1.5

–

–

–

1.7 ± 1.8

–

1.6 ± 1.5

 Severity

–

5.7 ± 2.7

–

6.9 ± 2.0

–

7.2 ± 1.3

–

–

–

–

–

6.9 ± 2.3

–

8.1 ± 2.0

ADI-R

 Social

–

19.0 ± 4.9

–

19.8 ± 6.1

–

20.1 ± 5.1

–

20.9 ± 3.0

–

20.2 ± 6.3

–

20.4 ± 4.7

–

–

 Verbal

–

14.3 ± 3.9

–

15.4 ± 4.7

–

16.8 ± 4.4

–

15.8 ± 3.7

–

16.4 ± 5.0

–

16.4 ± 4.6

–

–

 RRB

–

5.0 ± 2.3

–

6.4 ± 2.3

–

6.3 ± 2.6

–

6.6 ± 2.4

–

5.6 ± 2.7

–

7.2 ± 2.2

–

–

SRS

 Total

20.1 ± 16.0

86.2 ± 35.3

16.4 ± 9.5

93.6 ± 32.3

20.2 ± 15.7

95.3 ± 27.1

–

–

–

–

–

–

16.8 ± 13.1

95.8 ± 33.6

 Aware

5.0 ± 3.3

10.8 ± 3.8

4.0 ± 2.4

13.8 ± 3.7

4.0 ± 2.7

13.1 ± 3.6

–

–

–

–

–

–

4.6 ± 2.9

12.4 ± 3.2

 Cognit

2.6 ± 2.2

16.2 ± 5.1

2.5 ± 2.3

16.2 ± 7.2

3.5 ± 3.8

14.7 ± 6.0

–

–

–

–

–

–

3.0 ± 2.0

17.4 ± 6.5

 Comm

6.6 ± 6.8

28.4 ± 11.0

4.8 ± 3.8

32.1 ± 10.6

6.4 ± 5.5

32.8 ± 11.0

–

–

–

–

–

–

7.0 ± 5.1

37.0 ± 12.9

 Motiva

3.9 ± 3.3

13.0 ± 5.6

3.4 ± 2.6

13.6 ± 7.9

3.9 ± 3.3

14.8 ± 5.8

–

–

–

–

–

–

4.6 ± 5.1

19.1 ± 8.1

 Manner

2.0 ± 3.4

15.4 ± 6.0

1.7 ± 1.7

17.9 ± 7.5

2.3 ± 3.1

20.0 ± 5.7

–

–

–

–

–

–

2.4 ± 2.9

22.4 ± 6.9

  1. Abbreviations: GU, Georgetown University; KKI, Kennedy Krieger Institute; OHSU, Oregon Health and Science University; PITT, University of Pittsburgh School of Medicine; TRINITY, Trinity Centre for Health Sciences; UCLA, University of California, Los Angeles; USM, University of Utah School of Medicine; HC, healthy control; ASD, autism spectrum disorder; N, number; A, autism type; AS, Asperger syndrome type; P, pervasive developmental disorder type; NA, not applicable; ADOS, autism diagnostic observation schedule; IQ, intelligence quotient; FIQ, full-scale IQ; VIQ, verbal IQ; PIQ, performance IQ; Comm, communication, RRB, stereotyped behaviors and restricted interests; ADOS Total = social + communication; ADI-R, autism diagnostic interview revised; SRS, social responsiveness scale; Aware, awareness; Cognit, cognition; Motiva, motivation; Manner, mannerisms; SRS Total = awareness + cognition + communication + motivation + mannerisms
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Molecular Autism

ISSN: 2040-2392