Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study

Table 3 Results from within-pair analyses with perinatal and postnatal risk loads as main predictors of categorical Neurodevelopmental conditions

	nr of NDC diagnoses b (95% CI), p-value, Z-score	ASD diagnosis RR (95% CI), p-value, Z-score	ADHD diagnosis RR (95% CI), p-value, Z-score	Other NDCs RR (95% CI), p-value, Z-score	ID RR (95% CI), p-value, Z-score
Perinatal risk load	0.22 (0.10, 0.34), 0.00038*, 3.55	1.78 (1.11, 2.84), 0.016, 2.41	1.38 (0.96, 1.99), 0.079, 1.76	2.25 (0.52, 9.72), 0.277, 1.09	1.94 (0.46, 8.13), 0.367, 0.90
Postnatal risk load	0.29 (0.05, 0.52), 0.019, 2.35	1.94 (1.11, 3.40), 0.020, 2.32	1.33 (0.81, 2.18), 0.264, 1.12	1.29 (0.60, 2.79), 0.513, 0.65	1.45 (1.03, 2.05), 0.035, 2.11

The results were obtained in separate models. For continuous outcomes linear regression was used, and for binary outcomes logistic risk ratios (RR) were used.
Bold indicates p < 0.05 uncorrected
ADHD = attention-deficit/hyperactivity disorder, ASD = autism spectrum disorder, CI = confidence Interval, ID = intellectual disability, NDCs = neurodevelopmental conditions (other NDCs includes e.g., communication disorders, specific learning disorders or motor disorders)
^*Significant result after correcting for multiple comparisons using Benjamin-Hochberg procedure with false discovery rate (FDR) set at 5%

ISSN: 2040-2392