Table 2 MRS quality metrics, tissue fractions and concentrations

Number of MRS datasets

GABA+

24

25

na

22

24

na

Glx

20

22

na

15

16

na

GSH

26

26

na

20

23

na

Fit error (%)

GABA+

6.4 (± 2.8)

8.2 (± 2.8)

*

7.5 (± 2.0)

6.8 (± 1.5)

ns

Glx

3.9 (± 0.8)

4.4 (± 1.1)

ns

5.3 (± 1.3)

5.0 (± 1.1)

ns

GSH

7.3 (± 2.0)

8.3 (± 2.6)

ns

14.5 (± 6.3)

10.9 (± 4.2)

*

Signal to noise ratio

GABA+

13.0 (± 3.8)

11.5 (± 3.3)

ns

12.9 (± 2.3)

11.9 (± 2.1)

ns

Glx

19.9 (± 4.5)

21.2 (± 6.1)

ns

17.6 (± 4.7)

16.6 (± 4.0)

ns

GSH

10.1 (± 1.9)

9.8 (± 1.8)

ns

9.0 (± 1.8)

8.6 (± 1.3)

ns

Water drift

0.03 (± 0.01)

0.03 (± 0.01)

ns

0.02 (± 0.00)

0.02 (± 0.00)

ns

Full-width at half-maximum

GABA+

21.9 (± 2.7)

22.5 (± 2.5)

ns

20.7 (± 2.1)

21.0 (± 2.2)

ns

Glx

14.2 (± 2.6)

13.6 (± 2.0)

ns

15.8 (± 3.8)

17.2 (± 5.2)

ns

GSH

8.7 (± 1.0)

8.9 (± 0.9)

ns

10.5 (± 2.7)

11.1 (± 2.5)

ns

Tissue fractions

Grey matter

65% (± 4)

66% (± 3)

ns

54% (± 5)

54% (± 4)

ns

White matter

25% (± 3)

24% (± 3)

ns

38% (± 6)

38% (± 5)

ns

Cerebrospinal fluid

10% (± 2)

10% (± 3)

ns

8% (± 3)

8% (± 3)

ns

Concentrations

GABA + (i.u.)

2.94 (± 0.72)

2.75 (± 0.61)

ns

2.85 (± 0.53)

2.83 (± 0.61)

ns

Glx (i.u.)

9.08 (± 2.90)

9.35 (± 2.60)

ns

8.12 (± 1.43)

9.90 (± 3.14)

*

GSH (i.u.)

0.93 (± 0.17)

0.92 (± 0.23)

ns

1.13 (± 0.40)

1.16 (± 0.36)

ns

Glx/GABA + ratio

3.75 (± 2.44)

3.73 (± 1.52)

ns

2.91 (± 0.68)

3.59 (± 1.50)

ns