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Fig. 3 | Molecular Autism

Fig. 3

From: Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome

Fig. 3

IGF-2 did not markedly improve motor deficits, seizure threshold, or object recognition in Ube3amat−/pat+ mice. a Horizontal and b vertical activity in an open field assay were reduced in Ube3amat−/pat+ mice (mat-/pat+) compared to wildtype littermates (Ube3amat+/pat+; mat+/pat+), but unaffected by IGF-2. c Center time did not differ among groups. d Latency to cross a thin beam was elevated in mat-/pat+ mice, but unchanged by IGF-2. e Accelerating rotarod performance was moderately improved by IGF-2 treatment in mat-/pat + mice, however only on the first day of testing. f Regardless of IGF-2 treatment, mat-/pat+ mice demonstrated a marble burying deficit and g mat-/pat+ mice were quicker to exhibit generalized clonus following pentylenetetrazol administration, which was unaffected by IGF-2. h All groups demonstrated intact novel object recognition as measured by more time spent investigating the novel object compared to the familiar object and by i novel object percent preference. Data are expressed as mean ± S.E.M. n = 10–22 mice/group. a-d, f, g *p < 0.05, main effect of genotype, two-way ANOVA. e *p < 0.05 vs. mat+/pat+ vehicle, Tukey’s multiple comparisons test following three-way ANOVA. h *p < 0.05, paired t-test with Holm-Sidak’s correction for multiple comparisons

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