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Table 2 Demographics of comorbidities and birth characteristics of probands

From: Prevalence and phenotypic impact of rare potentially damaging variants in autism spectrum disorder

Birth characteristics and comorbidities CMA probands (n = 996) WES probands (n = 808)
n (%) Average diagnosis age (y) for ASD (SD) n (%) Average diagnosis age (y) for ASD (SD)
HC—large1 40 (5%) 7.9 (7.3) 30 (5%) 8.4 (7.7)
HC—small2 87 (11%) 4.6 (5.9) 73 (11%) 4.0 (4.4)
Large for gestational age3 38 (5%) 7.6 (7.7) 30 (4%) 5.2 (5.7)
Small for gestational age4 37 (5%) 4.1 (6.1) 35 (5%) 4.3 (6.3)
Congenital anomalies 74 (11%) 2.9 (4.9) 57 (10%) 3.1 (4.7)
Motor function disorders 55 (5%) 4.8 (5.0) 43 (5%) 4.6 (4.8)
Scholastic skill disorders 155 (16%) 5.1 (5.6) 121 (15%) 5.2 (6.2)
Speech/language disorders 133 (13%) 4.8 (5.8) 102 (13%) 4.6 (5.1)
ADHD 203 (20%) 8.4 (7.4) 160 (20%) 7.7 (7.2)
Anxiety disorder 29 (3%) 8.8 (6.5) 20 (2%) 9.5 (7.0)
Epilepsy 309 (31%) 5.5 (7.2) 255 (31%) 5.5 (7.2)
Intellectual disability 474 (48%) 6.5 (7.0) 381 (47%) 6.5 (7.1)
OCD 79 (8%) 9.0 (7.4) 70 (9%) 9.6 (7.8)
Psychotic disorders 86 (9%) 13.9(10.2) 67 (8%) 11.7 (9.8)
  1. ADHD attention-deficit/hyperactivity disorder, OCD obsessive–compulsive disorder
  2. 1HC-large if head circumference was > 38 cm. 2HC-small if head circumference was < 32 cm. 3Large for gestational age was defined as birth weight > 2 SD using the Swedish growth charts. 4Small for gestational age was defined as birth weight < 2 SD using Swedish growth charts. Missing values for congenital anomalies (CMA Probands/WES Probands) 335/260, large for gestational age 206/139, small for gestational age 206/139, HC-large 219/153, HC-small 219/153 individuals