Table 2 Demographics of comorbidities and birth characteristics of probands
From: Prevalence and phenotypic impact of rare potentially damaging variants in autism spectrum disorder
Birth characteristics and comorbidities | CMA probands (n = 996) | WES probands (n = 808) | ||
|---|---|---|---|---|
n (%) | Average diagnosis age (y) for ASD (SD) | n (%) | Average diagnosis age (y) for ASD (SD) | |
HC—large1 | 40 (5%) | 7.9 (7.3) | 30 (5%) | 8.4 (7.7) |
HC—small2 | 87 (11%) | 4.6 (5.9) | 73 (11%) | 4.0 (4.4) |
Large for gestational age3 | 38 (5%) | 7.6 (7.7) | 30 (4%) | 5.2 (5.7) |
Small for gestational age4 | 37 (5%) | 4.1 (6.1) | 35 (5%) | 4.3 (6.3) |
Congenital anomalies | 74 (11%) | 2.9 (4.9) | 57 (10%) | 3.1 (4.7) |
Motor function disorders | 55 (5%) | 4.8 (5.0) | 43 (5%) | 4.6 (4.8) |
Scholastic skill disorders | 155 (16%) | 5.1 (5.6) | 121 (15%) | 5.2 (6.2) |
Speech/language disorders | 133 (13%) | 4.8 (5.8) | 102 (13%) | 4.6 (5.1) |
ADHD | 203 (20%) | 8.4 (7.4) | 160 (20%) | 7.7 (7.2) |
Anxiety disorder | 29 (3%) | 8.8 (6.5) | 20 (2%) | 9.5 (7.0) |
Epilepsy | 309 (31%) | 5.5 (7.2) | 255 (31%) | 5.5 (7.2) |
Intellectual disability | 474 (48%) | 6.5 (7.0) | 381 (47%) | 6.5 (7.1) |
OCD | 79 (8%) | 9.0 (7.4) | 70 (9%) | 9.6 (7.8) |
Psychotic disorders | 86 (9%) | 13.9(10.2) | 67 (8%) | 11.7 (9.8) |