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Table 2 Comparison across groups of mean change from baseline to week 12

From: A randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome

Measure Variable name Number of subjects placebo Mean change placebo Median change placebo Number of subjects oxytocin Mean change oxytocin Median change oxytocin Mann–Whitney U test statistic Two-sided p-value
ABC          
  Irritability 9  − 5  − 3 7  − 1.71 0 40.5 0.351
  Social withdrawal 9  − 7.44  − 7 7  − 2.42  − 3 50 0.055
  Stereotypy 9  − 2.22  − 1 7 0.57 0 41.5 0.299
  Hyperactivity 9  − 8.11  − 6 7  − 2.71 0 42 0.299
  Inappropriate speech 9  − 1.67 0 7  − 7.14 0 35 0.758
RBS-R          
  Stereotypic behaviors 9  − 1.67  − 2 7 0.29 0 43 0.252
  Self-injury 9  − 1.22 0 7 1 0 46 0.142
  Compulsive behaviors 9  − 1.56 0 7  − 0.14 0 38 0.536
  Ritualistic behaviors 9  − 1.33  − 1 7  − 0.43 0 39 0.47
  Sameness behaviors 9  − 2  − 1 7  − 0.29  − 1 41 0.351
  Restricted behaviors 9  − 1.43 0 7 0.14 0 23.5 0.902
  Overall score 9  − 8.56  − 3 7 0 0 46 0.142
CGI-I          
  Severity 9  − 0.11 0 7  − 0.14 0 30.5 0.918
  Improvement* 9 N/A N/A 7 N/A N/A 38 0.536
SSP          
  Tactile 9 2.56 2 7 1.57 0 29 0.837
  Taste/smell 9 1.67 0 7 0.71 0 28.5 0.758
  Movement 9  − 0.67 0 7 0.29 0 41.5 0.299
  Under-responsive/seeks sensation 9 4.44 6 7 0.71 2 19 0.21
  Auditory filtering 9 4 3 7 0.29  − 1 16 0.114
  Low energy/weak 9 1.67 2 7  − 0.71 0 24 0.47
  Visual/auditory sensitivity 9 1.89 3 7  − 0.86 0 13 0.055
  Total 9 14.33 8 7 1  − 8 14.5 0.071
Vineland-II          
  Communication 7 4 0 6 2.83 2 22 1
  Daily living skills 7 3.29 1 6 1.17 0.5 14.5 0.366
  Socialization 7 3 1 6  − 0.5  − 0.5 12 0.234
  Motor 6 1 0 6 3.17 0 20.5 0.699
  Adaptive behavior composite 7 3.14 2 6 2 2 21 1
  Internalizing 7  − 1.14  − 1 6  − 0.5 0 29 0.295
  Externalizing 7  − 1.14  − 1 6  − 0.17 0 25.5 0.534
  Maladaptive 6  − 1.33 0 6  − 0.5  − 0.5 18 1
MSEL          
  Gross motor 7  − 1.57 0 7  − 0.86 0 22 0.805
  Visual reception 7 0.29 0 7 2.86 4 34 0.259
  Fine motor 7  − 0.29 0 7 0.71 0 32 0.383
  Receptive language 7  − 1.86  − 1 7 1.71 1 35.5 0.165
  Expressive language 7 0.43 0 7 0.43 0 22 0.805
MCDI          
  Phrases understood 7 0.71 0 7 1.43 0 29.5 0.535
  Words understood 7  − 8.14 0 7 7 1 29 0.62
  Words produced 7  − 8.43 0 7 2.57 0 23 0.902
  Early gestures 7 1.86 1 7  − 0.27 0 9 0.053
  Later gestures 7 2.71 1 7 0.86 1 26 0.902
  Total gestures 7 4.57 1 7 0.57 1 18 0.456
  1. *CGI-I scores reflect results at Week 12 only; Vineland-II domain and composite values are standard scores; MSEL values are age equivalents
  2. ABC Aberrant Behavior Checklist; AE age equivalent; CGI Clinical Global Impression-Improvement Scale; MCDI Macarthur-Bates Communicative Development Inventory; MSEL Mullen Scales of Early Learning; RBS Repetitive Behavior Scale-Revised; SSP Short Sensory Profile