Skip to main content

Table 4 ROI analysis of DTI and NODDI measures in participants with autism compared to TD

From: Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

  Autism TD P-value Cohen’s d
Mean SD Mean SD
DTI       
FA       
 Forceps minor 0.506 0.034 0.536 0.026 0.00017 0.96
 Genu of CC 0.707 0.022 0.732 0.025 0.00027 1.04
 Body of CC 0.730 0.026 0.764 0.022 0.0000095 1.44
 Forceps major 0.728 0.020 0.744 0.016 0.0021 0.90
 Left IFOF 0.487 0.026 0.516 0.031 0.00020 1.00
 Left SLF 0.479 0.034 0.521 0.033 0.000023 1.25
MD       
 Forceps minor 0.776 0.024 0.745 0.021 0.000059  − 1.36
 Body of CC 0.834 0.035 0.789 0.029 0.000049  − 1.39
 Splenium of CC 0.782 0.030 0.742 0.026 0.000031  − 1.43
 Forceps major 0.821 0.026 0.790 0.018 0.000016  − 1.38
 Left ALIC 0.716 0.024 0.685 0.020 0.000024  − 1.42
 Left ATR 1.038 0.138 0.889 0.140 0.00033  − 1.08
 Left IFOF 0.830 0.026 0.796 0.020 0.0000089  − 1.48
 Left ILF 0.862 0.027 0.828 0.021 0.000015  − 1.42
 Left SLF 0.763 0.021 0.736 0.018 0.000024  − 1.40
 Left UF 0.813 0.028 0.780 0.018 0.000020  − 1.39
 Left PLIC 0.747 0.026 0.724 0.017 0.0015  − 1.07
 Right ALIC 0.734 0.046 0.692 0.021 0.00010  − 1.19
 Right IFOF 0.780 0.025 0.750 0.020 0.000027  − 1.32
 Right ILF 0.789 0.024 0.762 0.020 0.000056  − 1.24
 Right SLF 0.709 0.021 0.688 0.018 0.00023  − 1.08
 Right UF 0.804 0.043 0.763 0.018 0.000030  − 1.24
RD       
 Forceps minor 0.496 0.027 0.465 0.024 0.000068  − 1.22
 Genu of CC 0.363 0.029 0.330 0.032 0.00059  − 1.07
 Body of CC 0.379 0.034 0.333 0.032 0.000026  − 1.40
 Splenium of CC 0.297 0.026 0.263 0.021 0.0000025  − 1.46
 Forceps major 0.395 0.025 0.358 0.021 0.00000083  − 1.59
 Left ALIC 0.461 0.037 0.424 0.021 0.000057  − 1.23
 Left ATR 0.733 0.108 0.609 0.108 0.00011  − 1.15
 Left IFOF 0.531 0.027 0.500 0.023 0.000028  − 1.26
 Left ILF 0.580 0.028 0.545 0.023 0.000012  − 1.39
 Left SLF 0.530 0.024 0.501 0.021 0.000085  − 1.26
 Left UF 0.562 0.029 0.523 0.025 0.000012  − 1.41
 Right ALIC 0.408 0.030 0.377 0.019 0.000088  − 1.25
 Right ATR 0.570 0.051 0.507 0.036 0.000014  − 1.42
 Right ILF 0.542 0.032 0.512 0.022 0.00027  − 1.11
 Right SLF 0.474 0.024 0.449 0.023 0.00017  − 1.04
 Right UF 0.505 0.034 0.470 0.022 0.000020  − 1.24
NODDI       
NDI       
 Forceps minor 0.588 0.031 0.627 0.022 0.0000043 1.46
 Genu of CC 0.651 0.039 0.687 0.032 0.00037 1.01
 Body of CC 0.689 0.036 0.732 0.034 0.00022 1.22
 Left ALIC 0.581 0.040 0.622 0.041 0.00023 1.01
 Left ATR 0.579 0.032 0.619 0.028 0.000016 1.32
 Left IFOF 0.608 0.038 0.648 0.028 0.00013 1.17
 Left UF 0.587 0.045 0.629 0.032 0.00017 1.06
 Right IFOF 0.567 0.037 0.604 0.028 0.00020 1.12
 Right ILF 0.549 0.032 0.583 0.027 0.00035 1.12
 Right SLF 0.668 0.028 0.700 0.028 0.00024 1.14
 Right UF 0.489 0.024 0.518 0.031 0.00031 1.02
ISOFV       
 Body of CC 0.161 0.027 0.124 0.017 0.0000018  − 1.65
 Splenium of CC 0.142 0.019 0.112 0.016 0.0000011  − 1.67
 Forceps major 0.137 0.017 0.113 0.014 0.00000027  − 1.56
 Left IFOF 0.160 0.031 0.125 0.019 0.000032  − 1.35
 Left ILF 0.134 0.026 0.102 0.019 0.000015  − 1.43
 Left SLF 0.125 0.018 0.098 0.010 0.000000065  − 1.84
  1. ALIC, anterior limb of internal capsule; ATR, anterior thalamic, radiation; CC, corpus callosum; DTI, diffusion tensor imaging; FA, fractional anisotropy; IFOF, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; ISOVF, isotropic volume fraction; MD, mean diffusivity; NDI, neurite density index; NODDI, neurite orientation dispersion and density imaging; PLIC, posterior limb of internal capsule; RD, radial diffusivity; ROI, region-of-interest; SLF, superior longitudinal fasciculus; TD, typically developing subjects; UF, uncinate fasciculus
Back to article page

Molecular Autism

ISSN: 2040-2392