Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

Andica, Christina; Kamagata, Koji; Kirino, Eiji; Uchida, Wataru; Irie, Ryusuke; Murata, Syo; Aoki, Shigeki

doi:10.1186/s13229-021-00456-4

Molecular Autism

Table 4 ROI analysis of DTI and NODDI measures in participants with autism compared to TD

From: Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

	Autism		TD		P-value	Cohen’s d
	Mean	SD	Mean	SD	P-value	Cohen’s d
DTI
FA
Forceps minor	0.506	0.034	0.536	0.026	0.00017	0.96
Genu of CC	0.707	0.022	0.732	0.025	0.00027	1.04
Body of CC	0.730	0.026	0.764	0.022	0.0000095	1.44
Forceps major	0.728	0.020	0.744	0.016	0.0021	0.90
Left IFOF	0.487	0.026	0.516	0.031	0.00020	1.00
Left SLF	0.479	0.034	0.521	0.033	0.000023	1.25
MD
Forceps minor	0.776	0.024	0.745	0.021	0.000059	− 1.36
Body of CC	0.834	0.035	0.789	0.029	0.000049	− 1.39
Splenium of CC	0.782	0.030	0.742	0.026	0.000031	− 1.43
Forceps major	0.821	0.026	0.790	0.018	0.000016	− 1.38
Left ALIC	0.716	0.024	0.685	0.020	0.000024	− 1.42
Left ATR	1.038	0.138	0.889	0.140	0.00033	− 1.08
Left IFOF	0.830	0.026	0.796	0.020	0.0000089	− 1.48
Left ILF	0.862	0.027	0.828	0.021	0.000015	− 1.42
Left SLF	0.763	0.021	0.736	0.018	0.000024	− 1.40
Left UF	0.813	0.028	0.780	0.018	0.000020	− 1.39
Left PLIC	0.747	0.026	0.724	0.017	0.0015	− 1.07
Right ALIC	0.734	0.046	0.692	0.021	0.00010	− 1.19
Right IFOF	0.780	0.025	0.750	0.020	0.000027	− 1.32
Right ILF	0.789	0.024	0.762	0.020	0.000056	− 1.24
Right SLF	0.709	0.021	0.688	0.018	0.00023	− 1.08
Right UF	0.804	0.043	0.763	0.018	0.000030	− 1.24
RD
Forceps minor	0.496	0.027	0.465	0.024	0.000068	− 1.22
Genu of CC	0.363	0.029	0.330	0.032	0.00059	− 1.07
Body of CC	0.379	0.034	0.333	0.032	0.000026	− 1.40
Splenium of CC	0.297	0.026	0.263	0.021	0.0000025	− 1.46
Forceps major	0.395	0.025	0.358	0.021	0.00000083	− 1.59
Left ALIC	0.461	0.037	0.424	0.021	0.000057	− 1.23
Left ATR	0.733	0.108	0.609	0.108	0.00011	− 1.15
Left IFOF	0.531	0.027	0.500	0.023	0.000028	− 1.26
Left ILF	0.580	0.028	0.545	0.023	0.000012	− 1.39
Left SLF	0.530	0.024	0.501	0.021	0.000085	− 1.26
Left UF	0.562	0.029	0.523	0.025	0.000012	− 1.41
Right ALIC	0.408	0.030	0.377	0.019	0.000088	− 1.25
Right ATR	0.570	0.051	0.507	0.036	0.000014	− 1.42
Right ILF	0.542	0.032	0.512	0.022	0.00027	− 1.11
Right SLF	0.474	0.024	0.449	0.023	0.00017	− 1.04
Right UF	0.505	0.034	0.470	0.022	0.000020	− 1.24
NODDI
NDI
Forceps minor	0.588	0.031	0.627	0.022	0.0000043	1.46
Genu of CC	0.651	0.039	0.687	0.032	0.00037	1.01
Body of CC	0.689	0.036	0.732	0.034	0.00022	1.22
Left ALIC	0.581	0.040	0.622	0.041	0.00023	1.01
Left ATR	0.579	0.032	0.619	0.028	0.000016	1.32
Left IFOF	0.608	0.038	0.648	0.028	0.00013	1.17
Left UF	0.587	0.045	0.629	0.032	0.00017	1.06
Right IFOF	0.567	0.037	0.604	0.028	0.00020	1.12
Right ILF	0.549	0.032	0.583	0.027	0.00035	1.12
Right SLF	0.668	0.028	0.700	0.028	0.00024	1.14
Right UF	0.489	0.024	0.518	0.031	0.00031	1.02
ISOFV
Body of CC	0.161	0.027	0.124	0.017	0.0000018	− 1.65
Splenium of CC	0.142	0.019	0.112	0.016	0.0000011	− 1.67
Forceps major	0.137	0.017	0.113	0.014	0.00000027	− 1.56
Left IFOF	0.160	0.031	0.125	0.019	0.000032	− 1.35
Left ILF	0.134	0.026	0.102	0.019	0.000015	− 1.43
Left SLF	0.125	0.018	0.098	0.010	0.000000065	− 1.84

ALIC, anterior limb of internal capsule; ATR, anterior thalamic, radiation; CC, corpus callosum; DTI, diffusion tensor imaging; FA, fractional anisotropy; IFOF, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; ISOVF, isotropic volume fraction; MD, mean diffusivity; NDI, neurite density index; NODDI, neurite orientation dispersion and density imaging; PLIC, posterior limb of internal capsule; RD, radial diffusivity; ROI, region-of-interest; SLF, superior longitudinal fasciculus; TD, typically developing subjects; UF, uncinate fasciculus

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ISSN: 2040-2392

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