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Table 3 Comparison of tract-based spatial statistics analysis of DTI and NODDI measures in participants

From: Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

Modality Contrast Significant voxels Anatomical region Mean (range) T-value Peak MNI coordinates (X, Y, Z)
DTI
 FA Autism < TD 4229 Bilateral ACR, SCR; Left ATR, CST, IFOF, UF, PCR; Forceps minor, genu, body, and splenium of CC 1.88 (1.07−6.09) 108, 120, 106
 MD Autism > TD 17,006 Bilateral ATR, CST, IFOF, ILF, SLF, UF, ALIC, PLIC, retrolenticular part of IC, ACR, SCR, PCR, PTR, sagittal stratum, and SFOF; Left-CCG and CgH; Right-external capsule; Forceps major and minor, genu, body, and splenium of CC, and fornix 1.61 (0.81–5.39) 48, 107, 107
 RD Autism > TD 20,728 Bilateral ATR, CST, CCG, IFOF, ILF, SLF, UF, ALIC, PLIC, retrolenticular part of IC, ACR, SCR, PCR, PTR, sagittal stratum, external capsule, and SFOF; Left-CgH; Right SLF temporal part; Forceps major and minor, genu, body, and splenium of CC, and fornix 1.61 (0.81−6.27) 144, 94, 102
NODDI      
 NDI Autism < TD 4110 Bilateral IFOF, UF, and external capsule; Left ATR, ALIC, and ACR; Right CST, ILF, SLF, retrolenticular part of IC, SLF temporal part, SCR, PCR, and PTR; Forceps major and minor, genu and body of CC 1.92 (1.07−4.84) 109, 168, 94
 ISOVF Autism > TD 2472 Left IFOF, ILF, SLF, UF, PLIC, retrolenticular part of IC, SCR, PCR, and PTR; Right-sagittal stratum; Forceps major, body, and splenium of CC 1.77 (1.04 − 4.74) 119, 101, 80
  1. ACR, anterior corona radiata; ALIC, anterior limb of internal capsule; ATR, anterior thalamic, radiation; CCG, cingulum cingulate gyrus; CgH, cingulum hippocampus; CP, cerebral peduncle; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; IC, internal capsule; IFOF, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; ISOVF, isotropic volume fraction; MD, mean diffusivity; MNI, Montreal Neurological Institute; NDI, neurite density index; NODDI, neurite orientation dispersion and density imaging; PCR, posterior corona radiata; PLIC, posterior limb of internal capsule; PTR, posterior thalamic radiation; RD, radial diffusivity; SCR, superior corona radiata; SFOF, superior fronto-occipital fasciculus; SLF, superior longitudinal fasciculus; UF, uncinate fasciculus; TD, typically developing subjects