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Table 1 The anatomical definition and functions of white matter tracts frequently involved in autism

From: Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

White matter tracts



Function related to autism


Projection fiber

Dorsomedial thalamic nucleus to prefrontal cortex through the anterior limb of internal capsule

Executive function and planning complex behaviors

Corpus callosum

Commissural fiber

The cortices of the two cerebral hemispheres

Cognitive and social function


Long-range associative fiber

Cingulate gyrus to the anterior thalamic nuclei

Visuospatial processing and memory access


Long-range associative fiber

Occipital cortex, temporo-basal areas, and superior parietal lobe to the frontal lobe

Semantic processing


Long-range associative fiber

Occipital lobe to the anterior temporal lobe

Face and emotion recognition


Long-range associative fiber

Frontal lobe to parietal lobe and partially to temporal lobe

Visuospatial attention, language auditory comprehension, articulatory processing, reading, and lexical access


Long-range associative fiber

Lateral orbitofrontal cortex and Broadmann area 10 to anterior temporal lobes

Episodic memory, language, and social emotional processing

  1. ATR, anterior thalamic radiation; IFOF, inferior fronto- occipital fasciculus; ILF, inferior longitudinal fasciculus; SLF, superior longitudinal fasciculus; UF, uncinate fasciculus