Fig. 2

Masculinity as measured by digit ratio and facial landmarks. a Hand scans from devGenes participants were used to measure digit lengths and subsequently the ratio between the index and ring fingers (2D:4D ratio). b Cross-sectional data were collected from individuals spanning from age 2 to age 80. The 95% interval of the lowess trend of 2D:4D ratio vs. age for typically developing males and females is shown. c, d The 2D:4D ratio of affected males and affected females is shown with respect to the 95% confidence interval for their typically developing counterparts, with accompanying empirical p values. e Facial photographs from devGenes participants were used to calculate facial masculinity using a Random Forest classifier. f The lowess trends and 95% confidence interval for typically developing males and females is shown. g, h The facial masculinity of affected males and affected females is shown with respect to the 95% confidence interval for their typically developing counterparts, with empirical p values