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Fig. 6 | Molecular Autism

Fig. 6

From: Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity

Fig. 6

Overexpression of oxytocin in paraventricular nucleus (PVN) of the hypothalamus of six-week-old Pten+/+ and PtenY68H/+ mice. a Representative immunofluorescence staining of six-week-old Pten+/+ and PtenWT/Y68H PVN for Oxt (green) and DAPI (blue). N = 3. Magnification = 10X. Scale bar = 166 μm. b Quantification of the integrated density of Oxt stain per biological replicate, finding a significant increase in Oxt in the PtenY68H/+ PVN compared to Pten+/+ PVN (P = 0.032). c Western analysis for Oxt expression in of six-week-old Pten+/+ and PtenY68H/+ hypothalamus (N = 5). d Quantification of Western in panel c (P = 0.0079). P value key: *P < 0.05, **P < 0.01

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Molecular Autism

ISSN: 2040-2392