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Table 9 Mean biomarker gene expression at 15 weeks of exposure to sulforaphane by presence or absence of fever effect (natural log transformed values for change from baseline)

From: Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

  Fever effect
N
Fever effect
Mean (95% CI)
No fever effect
N
No fever effect
Mean (95% CI)
p value
NQO1 16 0.33 (− 0.34, 1.00) 20 0.93 (0.26, 1.60) 0.196
xCT 17 − 0.24 (− 0.72, 0.23) 21 0.51 (0.02, 0.99) 0.027
HO-1 17 − 0.45 (− 1.08, 0.18) 21 − 0.40 (− 1.07, 0.28) 0.906
HSP70 17 0.02 (− 0.22, 0.26) 21 − 0.35 (− 0.60, − 0.09) 0.037
HSP27 17 − 0.52 (− 1.12, 0.08) 21 − 0.70 (− 1.42, 0.02) 0.697
IL-6 17 − 1.59 (− 2.21, − 0.98) 20 − 0.98 (− 1.69, − 0.27) 0.187
IL-1β 16 − 0.61 (− 1.27, 0.06) 20 − 1.12 (− 2.22, − 0.02) 0.434
COX-2 17 0.08 (− 0.26, 0.41) 21 − 0.36 (− 0.55, − 0.18) 0.015
TNF-α 17 − 0.30 (− 0.68, 0.07) 21 − 0.89 (− 1.32, − 0.46) 0.043
  1. Bold signifies p < 0.05
  2. p value based on t test