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Fig. 1 | Molecular Autism

Fig. 1

From: Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development

Fig. 1

Arid1b model validation and differential expression in adult cerebellum. a Quantitative reverse-transcription PCR (qRT-PCR) showed reduced mRNA levels of Arid1b in Arid1b+/− mice compared to wildtype in cortex and cerebellum lysates. Western blot quantitation showed significantly lower relative expression of ARID1B in both the b cortex and c cerebellum of Arid1b+/− mice compared to wildtype. For ac Arid1b+/+ N = 3, Arid1b+/− N = 3, mixed sex. *p < 0.05, Student’s t test. Error bars represent mean ± SEM. d Heatmap showing relative expression in Arid1b+/+ and Arid1b+/− (HT) adult cerebellum for 72 differentially expressed (DE) genes (EdgeR GLM FDR < 0.05, N = 1 male and female each per genotype). e Bar plot showing logRPKM Arid1b expression. f Representative GO terms enriched among DE genes (FDR < 0.2).DE and All: DE and total gene count annotated to GO term. GO Term: GO accession, description, and ontology class (Biological Pathway (BP), Molecular Function (MF), Cellular Component (CC)). FDR: goseq FDR for enrichment

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