Skip to main content

Table 2 Summary statistics for clinical measures

From: Prospective and detailed behavioral phenotyping in DDX3X syndrome

Domain

Evaluation

Variable

n

Range

Mean

SD

% with atypical score

Intellectual and Adaptive Functioning

Mullen Scales, Stanford-Binet-5, DAS-II1

Full scale DQ

15

9.9–97.8

34.1

22.5

93

Nonverbal DQ

15

14.1–78.4

34.1

16.8

93

Verbal DQ

15

5.8–117.3

35.1

28.7

93

Vineland-32

Communication

15

20–87

43.7

24.7

87

Daily Living Skills

15

20–73

48.6

17.5

100

Socialization

15

20–90

55.3

20.6

87

Adaptive Behavior Composite

15

20–76

49.5

18.8

100

Motor Functioning

ADI-R, Psychiatric Evaluation2

Age of crawling (months)

15

5–24

15.2

6.0

87

Age of walking independently (months)

13

11–36

26

8.1

93

Vineland-32

Motor Skills

10

20–77

57.6

18.6

100

Fine Motor

10

1–10

6.0

3.7

100

Gross Motor

10

1–12

7.9

4.3

60

VMI-63

Standard score

13

< 45–87

68.3

10.0

85

DCDQ4

Total score

8

15–45

23.8

9.7

100

Expressive and Receptive Language

ADI-R, Psychiatric Evaluation2

Age of first word (months)

10

15–60

28.7

14.0

87

Age of phrased speech (months)

7

36–60

48.6

9.8

100

Expressive Vocabulary Test2

Standard score

7

44–123

77.6

23.5

57

Peabody Picture Vocabulary Test2

Standard score

13

20–111

59.7

31.2

69

Vineland-32

Expressive Language

15

1–14

3.6

4.3

93

Receptive Language

15

1–14

5.7

4.8

80

MacArthur-Bates Communicative Development Inventory

Words Understood

13

15–396

277.9

125.8

n/a

Words Produced

13

0–396

164.8

186.1

n/a

Early Gestures

13

6–18

12.7

4.9

n/a

Later Gestures

13

4–45

27.2

15.4

n/a

Total Gestures

13

10–63

39.9

19.5

n/a

ASD Symptomatology

SRS-25

Total score

15

50–96

68.9

14.0

73

Social Communication

15

48–94

69.7

16.4

60

Social Awareness

15

56–90

70.4

10.6

80

Social Cognition

15

51–84

66.8

10.7

80

Repetitive Behavior

15

52–90

72.6

13.5

80

Social Motivation

15

38–86

58.2

14.1

47

RBS-R

Insistence on Sameness

14

0–9

2.57

2.93

n/a

Stereotyped Behavior

14

0–6

2.64

2.02

n/a

Sensory Features

SAND2

Sensory seeking

15

7–28

17.27

7.3

87

Hyporeactivity

15

0–21

10.40

6.7

80

Hyperreactivity

15

2–11

5.67

3.5

47

Tactile

15

2–19

13.67

4.5

93

Auditory

15

0–23

10.6

6.3

73

Visual

15

0–17

9.07

5.5

73

Behavioral Comorbidities

CBCL6

Internalizing

14

33–69

53.50

9.51

14

Depressive

14

50–77

58.86

8.42

21

Anxiety

14

50–76

54.71

7.06

14

Externalizing

14

44–73

58.43

8.11

21

ADHD

14

54–72

64.29

6.60

50

Oppositional/Defiant

14

51–64

54.71

5.30

0

Aberrant Behavior Checklist5

Hyperactivity

15

< 40–65

53.60

7.50

20

Irritability

15

< 40–67

50.67

9.79

13

Lethargy/Social Withdrawal

15

< 40–60

48.11

7.64

7

Stereotypy

15

40–73

49.53

10.14

20

Inappropriate Speech

15

40–67

48.93

8.03

7

Vineland-32

Internalizing Behavior

15

15–22

18.5

2.2

33

Externalizing Behavior

15

11–21

17.5

2.6

20

  1. DAS-II: Differential Abilities Scales, Second Edition; ADI-R: Autism Diagnostic Interview-Revised; VMI-6: Beery-Buktenica Developmental Test of Visual-Motor Integration, Sixth Edition; DCDQ: Developmental Coordination Disorder Questionnaire; SRS-2: Social Responsiveness Scale, Second Edition; RBS-R: Repetitive Behavior Scales-Revised; SAND: Sensory Assessment for Neurodevelopmental Disorders; CBCL: Achenbach Child Behavior Checklist
  2. 1Atypical if < 77.5
  3. 2Atypical if standard score 1.5 SD above or below population mean
  4. 3Atypical if standard score < 50, per manual
  5. 4Atypical if score 15–46 (5 y–7 y 11 m), 15–55 (8 y–9 y 11 m), 15–57 (10 y–15 y)
  6. 5Atypical if T score > 60
  7. 6Atypical if T score > 65
Back to article page

Molecular Autism

ISSN: 2040-2392