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Table 6 Clinical summary of elevated and equivocal risk for each type of sleep disorder in each syndrome

From: Sleep disorders in rare genetic syndromes: a meta-analysis of prevalence and profile

Syndrome Sleep-related breathing difficulties Insomnia Excessive daytime sleepiness Sleep Enuresis Sleep bruxism
Angelman + ++ + ++ +
CHARGE ++
Cornelia de Lange ++ ++ +
Cri du Chat
Down ++ ++ + + ++
Fragile X ++ + + ++ ++
Hurler ++
Jacobsen
Juvenile Neuronal Ceroid Lipofuscinosis
Mucopolysaccharidosis Type II ++
Mucopolysaccharidosis Type IIIB +
Mucopolysaccharidosis Type IVA ++
Neurofibromatosis + ++ ++
Prader–Willi ++ + + +
Rett + ++ + +
Smith–Magenis + ++
Smith–Lemli–Opitz
Tuberous Sclerosis Complex ++ ++
Williams ++ ++ + + +
  1. ++ indicates a sleep disorder which should be considered as part of a priority assessment in that syndrome, + a sleep disorder which should be considered as part of routine assessment, and – a sleep disorder where further research is needed