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Fig. 2 | Molecular Autism

Fig. 2

From: Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms

Fig. 2

Effects of intranasal oxytocin on changes in metabolite concentrations and time-course change in effects of oxytocin. ac Individual changes from baseline in the natural logarithm of the mode of the probability density function (log-PDFmode) of neutral facial expression intensity. Plots show changes from baseline of log-PDFmode of neutral facial expression intensity in participants administered placebo (a) or oxytocin (b). Among the participants administered with oxytocin, individuals showing reduction of log-PDFmode of neutral facial expression from baseline to 2 weeks and increase of log-PDFmode neutral facial expression from 2 to 6 weeks were classified as participants exhibiting a time-course change (c). d Plots show changes in plasma DMG levels during the 6-week administration of oxytocin or placebo. Bars indicate mean concentration change in each group

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