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Table 2 Anatomical location and statistics for BOLD activation

From: Modulation of atypical brain activation during executive functioning in autism: a pharmacological MRI study of tianeptine

Region X Y Z Cluster p value Cluster size
GO/NO-GO task (n = 17 for both groups)
ASD placebo vs TD placebo
ASD < TD (blue)
Right postcentral cortex 58 − 19 33 0.009 144
ASD > TD (red)
Right cerebellum 29 − 67 − 40 0.02 81
Right occipital cortex 11 − 96 − 7 0.01 114
Left inferior frontal cortex/left insula − 40 19 13 0.02 95
Right premotor cortex 43 − 7 50 0.01 111
ASD tianeptine vs TD placebo
ASD < TD (blue)
Right lingual cortex 11 − 100 − 3 0.007 45
Interaction of drug status (placebo, tianeptine) by group (ASD, TD)
Cerebellum bilaterally/limbic area
Right rostromedial frontal 25 − 19 − 20 0.008 357
Cortex/caudate/cingulate 29 59 7 0.009 376
Sustained attention task (n = 19 for both groups)
TD placebo vs ASD placebo
ASD < TD (blue)
Right Middle Temporal Cortex 61 − 7 − 7 0.02 212
Right cuneus 14 − 93 3 0.0008 1082
Left precuneus − 4 − 63 46 0.009 747
TD placebo vs ASD tianeptine
ASD < TD (blue)
Right cuneus 14 − 93 3 0.003 385
Interaction of drug status (placebo, tianeptine) by group (ASD, TD)
Right middle temporal cortex 40 − 56 10 0.01 204
Right thalamus 7 − 11 7 0.001 502
Left middle frontal cortex − 51 4 46 0.02 180
  1. X, Y, Z = Peak Talairach coordinates
  2. BOLD blood-oxygen-level-dependent, ASD Individuals with Autism Spectrum Disorder, TD Typically Developed Controls