Fig. 6

Ube3a-del mice exhibited reduced sleep spindle production that was significantly correlated with delta rhythmicity. Sleep spindles were automatically detected using a custom written Python script. a Ube3a-del mice had significantly less sleep spindles when compared to their wildtype littermate controls. When taking spindles as a fraction of total sleep time, b Ube3a-del animals had more spindle counts given their reduced sleep time, suggesting increased frequency of spindle counts during their infrequent sleep periods. To further analyze the Ube3a-del spindle count by reported sleep deficits c–f correlational analyses were run between spindles and total sleep time, mean time in slow-wave sleep, mean time in paradoxical sleep and latency to paradoxical sleep. No significant correlations were detected between spindle count and sleep. Additionally, f spindle production was correlated with spiking events to see if elevated spiking in Ube3a-del mice could predict spindle count, but no relationship was found. Finally, g spindle count was negatively correlated with delta power in Ube3a-del mice, where animals with enhanced delta had less spindles than animals with lower delta power. *p < 0.05, Student’s t test between genotype and linear regression for correlation across behaviors