Skip to main content
Fig. 5 | Molecular Autism

Fig. 5

From: Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome

Fig. 5

Sleep deficits observed in Ube3a-del mice are persistent across light–dark cycles. Sleep parameters were analyzed across light–dark cycles by sectioning the first 24-h time period into 2-h time bins starting at 12:00 a.m. (0–2 time of day). Time in each sleep stage, represented as percent of a 2-h time bin, and bouts of sleep stages, represented as counts per 2-h time bin, were examined. Both wake and active wake stages were combined for awake analysis. Grey boxes highlighting hours 7–19 indicate the dark cycle, while unhighlighted hours ranging from 0 to 7 and 19–24 indicate light cycle. a A trend toward increased percent time awake was detected in Ube3a-del mice compared to WT littermate controls (p = 0.105), b that was not specific to either the light or dark cycle. c Awake bouts were not significantly different between Ube3a-del mice compared to WT, and d no significant differences were observed between light and dark cycles. Interestingly, e Ube3a-del mice exhibited less percent paradoxical sleep time compared to WT controls that was f significant across both the light and dark cycles. g Likewise, paradoxical sleep bouts were significantly reduced in Ube3a-del mice compared to WT littermate controls, again h across both light and dark cycles. Both percent time (i) and bouts (k) of slow-wave sleep were not significantly different between genotypes or across light–dark cycles (j, l). *p < 0.05, Two-way RM ANOVA comparing genotypes across time bins and mixed model effects between genotype and light–dark cycle

Back to article page