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Fig. 3 | Molecular Autism

Fig. 3

From: Towards robust and replicable sex differences in the intrinsic brain function of autism

Fig. 3

Functional relevance of sex-by-diagnosis interaction in VMHC. a The radar plot shows the percentage (0–80%) of overlap between the voxels in the dorsolateral occipital cluster showing a significant VMHC sex-by-diagnosis interaction in discovery analyses and the 12 Yeo cognitive ontology probability maps [63] (probability threshold at P = 1e−5) for cognitive components C1–C12. As in Floris et al. [2], we labelled each component based on the top five tasks reported to be most likely recruited by a given component. b Word cloud based on the top 27 terms showing correlations between r = 0.64 to r = 0.10 associated with the same VMHC cluster based on the Neurosynth Image Decoder. c Sex-differential association between each individual’s VMHC at the cluster showing a significant sex-by-diagnosis interaction in primary analyses and available ADOS social-affect uncalibrated sub-scores in males and females with ASD. VMHC data are shown as residuals obtained after regressing out mean framewise displacement and age effects. While males showed no significant associations at corrected and uncorrected thresholds, females with lower dorsolateral occipital VMHC showed more severe social-affect symptoms at a uncorrected statistical threshold (F(1,311) = 4.44, p = 0.036)

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