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Table 4 Comparing PAC metrics across categorical phenotypes in Phelan-McDermid Syndrome

From: Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome

Measure

PAC median

Mann–Whitney U

P value

z-MI

–

–

–

 Sex

–

–

–

  Female

2.99 (1.19, 9.83)

2.16

.031

  Male

0.836 (0.512, 1.485)

–

–

 ASD diagnosis

–

–

–

  Yes

1.45 (0.337, 3.73)

-.712

.501

  No

1.60 (0.907, 6.71)

–

–

 SHANK3

–

–

–

  Deletion

1.22 (0.559, 4.98)

− .723

.497

  Mutation

1.59 (1.23, 9.63)

–

–

 Seizure history

–

–

–

  Yes

1.84 (.086, 9.50)

.371

.748

  No

1.23 (.626, 4.35)

–

–

Phase bias * 104

–

–

–

 Sex

–

–

–

  Female

5.00 (2.29, 15.7)

1.00

.336

  Male

3.67 (− 0.007, 5.17)

–

–

 ASD diagnosis

–

–

–

  Yes

4.28 (2.88, 15.5)

.876

.403

  No

3.33 (.534, 7.85)

–

–

 SHANK3

–

–

–

  Deletion

4.14 (0.210, 15.7)

.145

.910

  Mutation

4.04 (0.751, 7.57)

–

–

 Seizure history

–

–

–

  Yes

7.99 (− 1.85, 18.5)

.889

.409

  No

3.84 (1.42, 6.71)

–

–

  1. Median values (25th and 75th percentile values in parentheses) are presented for each category. All tests performed using a Mann–Whitney U test. A Benjamini–Hochberg correction was applied to ln(z-MI) and phase bias comparisons separately. * indicates significance (FDR = .1)