Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

Table 2 Brain volume differences relative to control wildtype littermates

Brain area	Chd8 genotype
Brain area	+/− (%)	neo/neo (%)
Brain volume	2.73	4.53**
Cortex	3.82⁻	5.53**
Cerebellum	3.41	6.99**
Hippocampus	5.97⁻	5.84**
Primary motor cortex	3.68⁻	6.68**
Primary somatosensory cortex	3.7⁻	5.62**
Primary auditory cortex	3.2	6.23**
Primary visual cortex	3.39	7.15**
Frontal cortex	3.99⁻	5.21**
Frontal association cortex	4.81⁻	6.07**
Entorhinal cortex	4.83⁻	7.05**
Cingulate cortex	4.57⁻	4.84**
Amygdala	3.82	4.64*

⁻FDR < 0.15; *FDR < 0.05; **FDR < 0.01. MRI data from Chd8^+/− and littermate control mice used for comparison are from Suetterlin et al. [18]

ISSN: 2040-2392