Table 2 PTEN pathway protein levels across groups and by ASD and PTEN status
| Â | (1) Macro-ASD | (2) PTEN no-ASD | (3) PTEN-ASD | F (p) | R2 | ASD | PTEN |
|---|---|---|---|---|---|---|---|
M (SD) n = 20 | M (SD) n = 16 | M (SD) n = 25 | β (p) | β (p) | |||
PTEN | 140.5 (41.7) | 121.1 (50.8) | 116.4 (47.4) | 1.59 (.213) | .05 |  − .04 (.754) |  − .24 (.045) |
P- AKT | 115.3 (42.0) | 126.5 (36.2) | 122.1 (38.5) | 0.38 (.686) | .01 |  − .05 (.722) | .08 (.568) |
Total AKT | 133.4 (75.3) | 139.1 (64.3) | 126.3 (64.9) | 0.18 (.838) | .01 |  − .08 (.561) |  − .05 (.730) |
P- ERK | 110.0 (57.0) | 130.0 (67.8) | 105.3 (54.2) | 0.90 (.411) | .03 |  − .19 (.196) |  − .04 (.790) |
Total ERK | 195.4 (79.5) | 194.5 (70.1) | 183.9 (72.5) | 0.17 (.847) | .01 |  − .06 (.657) |  − .08 (.606) |
IGFBP2 | 166.1 (41.3) | 180.4 (41.7) | 156.5 (54.4) | 1.25 (.295) | .04 | .22 (.120) |  − .69 (.498) |
MnSOD | 175.5 (48.9) | 202.2 (41.0) | 160.5 (46.9) | 4.00 (.024) | .12 |  − .38 (.006) |  − .15 (.284) |
P- S6 | 94.6 (58.6) | 67.1 (33.8) | 115.5 (59.3) | 3.54 (.035) | .11 | .36 (.010) | .17 (.226) |
S6 | 160.4 (47.6) | 145.2 (52.0) | 131.7 (43.4) | 2.07 (.136) | .07 |  − .13 (.373) |  − .28 (.047) |
EIF2A | 17.8 (5.1) | 19.9 (4.1) | 19.9 (4.5) | 1.54 (.222) | .05 |  − .01 (.962) | .22 (.120) |
p27 | 13.7 (5.7) | 16.4 (6.6) | 12.8 (7.4) | 1.43 (.248) | .05 |  − .24 (.100) |  − .07 (.649) |
P-AKT/AKT | 1.22 (1.11) | 1.17 (0.84) | 1.22 (0.64) | 0.02 (.978) |  < .01 | .05 (.848) |  < .01 (.999) |
P-ERK/ERK | 0.87 (0.95) | 0.91 (0.90) | 0.80 (0.69) | 0.10 (.903) |  < .01 |  − .12 (.666) |  − .08 (.770) |
P-S6/S6 | 0.64 (0.44) | 0.52 (0.27) | 0.88 (0.42) | 4.40 (.017) | .13 | .36 (.007) | .24 (.045) |