| |
(1) Macro-ASD
|
(2) PTEN no-ASD
|
(3) PTEN-ASD
|
F (p)
|
R2
|
ASD
|
PTEN
|
|---|
|
M (SD) n = 20
|
M (SD) n = 16
|
M (SD) n = 25
|
β (p)
|
β (p)
|
|---|
|
PTEN
|
140.5 (41.7)
|
121.1 (50.8)
|
116.4 (47.4)
|
1.59 (.213)
|
.05
|
− .04 (.754)
|
− .24 (.045)
|
|
P- AKT
|
115.3 (42.0)
|
126.5 (36.2)
|
122.1 (38.5)
|
0.38 (.686)
|
.01
|
− .05 (.722)
|
.08 (.568)
|
|
Total AKT
|
133.4 (75.3)
|
139.1 (64.3)
|
126.3 (64.9)
|
0.18 (.838)
|
.01
|
− .08 (.561)
|
− .05 (.730)
|
|
P- ERK
|
110.0 (57.0)
|
130.0 (67.8)
|
105.3 (54.2)
|
0.90 (.411)
|
.03
|
− .19 (.196)
|
− .04 (.790)
|
|
Total ERK
|
195.4 (79.5)
|
194.5 (70.1)
|
183.9 (72.5)
|
0.17 (.847)
|
.01
|
− .06 (.657)
|
− .08 (.606)
|
|
IGFBP2
|
166.1 (41.3)
|
180.4 (41.7)
|
156.5 (54.4)
|
1.25 (.295)
|
.04
|
.22 (.120)
|
− .69 (.498)
|
|
MnSOD
|
175.5 (48.9)
|
202.2 (41.0)
|
160.5 (46.9)
|
4.00 (.024)
|
.12
|
− .38 (.006)
|
− .15 (.284)
|
|
P- S6
|
94.6 (58.6)
|
67.1 (33.8)
|
115.5 (59.3)
|
3.54 (.035)
|
.11
|
.36 (.010)
|
.17 (.226)
|
|
S6
|
160.4 (47.6)
|
145.2 (52.0)
|
131.7 (43.4)
|
2.07 (.136)
|
.07
|
− .13 (.373)
|
− .28 (.047)
|
|
EIF2A
|
17.8 (5.1)
|
19.9 (4.1)
|
19.9 (4.5)
|
1.54 (.222)
|
.05
|
− .01 (.962)
|
.22 (.120)
|
|
p27
|
13.7 (5.7)
|
16.4 (6.6)
|
12.8 (7.4)
|
1.43 (.248)
|
.05
|
− .24 (.100)
|
− .07 (.649)
|
|
P-AKT/AKT
|
1.22 (1.11)
|
1.17 (0.84)
|
1.22 (0.64)
|
0.02 (.978)
|
< .01
|
.05 (.848)
|
< .01 (.999)
|
|
P-ERK/ERK
|
0.87 (0.95)
|
0.91 (0.90)
|
0.80 (0.69)
|
0.10 (.903)
|
< .01
|
− .12 (.666)
|
− .08 (.770)
|
|
P-S6/S6
|
0.64 (0.44)
|
0.52 (0.27)
|
0.88 (0.42)
|
4.40 (.017)
|
.13
|
.36 (.007)
|
.24 (.045)
|
- All protein levels are 10-e + 3. Bold designates p < .05, and italics designates p ≤ .10. Per a priori hypothesis, a one-tailed p value was used for evaluating the effect of PTEN mutations status on PTEN protein levels
