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Fig. 5 | Molecular Autism

Fig. 5

From: The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior

Fig. 5

Proposed model. a 4EHP binds to the mRNA 5′ cap where its stable expression and function is maintained and reciprocated by physical interaction with GIGYF2. b Homozygous deletion of 4EHP in excitatory neurons of the forebrain (4EHP-eKO) results in reduced protein expression of GIGYF2, exaggerated mGluR-LTD, and impaired social behavior (possibly due to translation de-repression of specific mRNAs without affecting global protein synthesis). c Heterozygous deletion of Gigyf2, Eif4e2, or both does not result in ASD-like behaviors (possibly due to haplosufficiency). d Proposed model for the development of ASD in patients harboring GIGYF2 mutations

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Molecular Autism

ISSN: 2040-2392