Fig. 8
From: Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats
PSD length was comparable, but HD and PSD area were higher in Shank3-Het. PSD length in a total synapses, b non-perforated synapses, and c perforated synapses are comparable among WT, Shank3-Het, and Shank3-KO rats. d HD in total synapses is wider in Shank3-Het rats compared to the WT. e HD in non-perforated synapses is wider in Shank3-Het rats compared to both WT and Shank3-KO, but non-perforated synapses in the Shank3-KO have similar HD as the WT. f HD of perforated synapses is comparable in WT, Shank3-Het, and Shank3-KO. The Shank3-Het group has greater PSD area of g total and h non-perforated synapses compared to the Shank3-KO, but the Shank3-KO and WT are comparable for these measures. i PSD area of perforated synapses is similar among the three groups. WT, wild-type; Het, Shank3 heterozygotes; KO, Shank3 knockouts. *p < 0.05 by one-way ANOVA followed by Tukey’s test compared to the indicated group