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Fig. 1 | Molecular Autism

Fig. 1

From: Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice

Fig. 1

Altered social dominance and social cooperative behaviors of Shank mutant mice. a Schematics of tube and social cooperation behavior tests. Left panel: Tube test design. Right panel: Social cooperation test design. b, c Analysis of social dominance of Shank2∆6–7 mice (b) and Shank3∆9 mice (c). Representative graphs showing comparable win percentages for Shank2∆6–7 and Shank3∆9 mice and their littermate controls. Data are expressed as means ± SEMs (*p < 0.05, **p < 0.01, ***p < 0.001; Mann–Whitney U test). ‘n’ denotes the number of mice analyzed: Ctrl (b), n = 10; Shank2∆6–7 (b), n = 9; Ctrl (c), n = 11; Shank3∆9 (c), n = 13. d, e Analysis of social cooperation in Shank2∆6–7 mice (d) and Shank3∆9 mice (e). The performance of Shank2∆6–7 or Shank3∆9 mice and their WT littermates in social cooperation tests was evaluated. Data are expressed as means ± SEMs (n denotes the number of mouse pairs analyzed; n = 6 (Ctrl, d); n = 7 (Shank2∆6–7, d); n = 6 (Ctrl, e), n = 10 (Shank3∆9, e); *p < 0.05, **p < 0.01, ****p < 0.0001; two-way repeated ANOVA). Mutual rewards (Genotype: F(1,9) = 1.583, p = 0.2400; Day: F(3.763, 33.87) = 8.463, p < 0.0001; Genotype x Day: F(11, 99) = 1.171, p = 0.3168, d; Genotype: F(1,14) = 25.52, p = 0.0002; Day: F(4.437, 62.12) = 7.205, p < 0.0001; Genotype x Day: F(11, 154) = 2.641, p = 0.0040, e), efficacy (Genotype: F(1,9) = 0.4601, p = 0.5146; Day: F(3.994,35.94) = 7.386, p = 0.0002; Genotype × Day: F(11,99) = 0.6153, p = 0.8119, d; Genotype: F(1,14) = 23.11, p = 0.0003; Day: F(5.091,71.27) = 5.113, p = 0.0004; Genotype × Day: F(11,154) = 1.969, p = 0.0350, e), latency (Genotype: F(1,9) = 0.04543, p = 0.8360; Day: F(4.166,37.49) = 5.841, p = 0.0008; Genotype × Day: F(11,99) = 0.7166, p = 0.7201, d; Genotype: F(1,14) = 16.28, p = 0.0012; Day: F(6.167,86.33) = 2.484, p = 0.0278; Genotype × Day: F(11,154) = 0.7885, p = 0.6512, e) and activity (Genotype: F(1,9) = 6.947, p = 0.0271; Day: F(3.226,29.04) = 7.820, p = 0.0004; Genotype × Day: F(11,99) = 1.418, p = 0.1766, d; Genotype: F(11,209) = 1.305, p = 0.0031; Day: F(5.485,104.2) = 2.674, p = 0.0220; and Genotype × Day: F(11,209) = 1.305, p = 0.2230, e). See also Additional file 1: Table S1 for summary

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