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Table 1 Gene expression changes between control and TSC patient neurons

From: Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation

Target gene RNA abundance (mean ± SEM) Change
Control neurons TSC neurons
GABAergic cells
DLX1 0.016 ± 0.009 0.002 ± 0.0004  
DLX2 0.03 ± 0.01 0.05 ± 0.01  
LHX6 0.08 ± 0.02 0.11 ± 0.02  
VGAT 0.03 ± 0.01 0.04 ± 0.01  
Synaptic
PSD95 0.21 ± 0.05 0.12 ± 0.02  
Synaptophysin 0.07 ± 0.01 0.11 ± 0.03  
Homer1 0.37 ± 0.07 0.43 ± 0.05  
GABA/glutamate signalling
GAD65 0.034 ± 0.02 0.17 ± 0.07*
GAD67 0.13 ± 0.07 1.74 ± 0.61**
GABAα1 0.33 ± 0.05 0.50 ± 0.02  
GABAα2 0.31 ± 0.06 1.14 ± 0.07***
GABAβ1 0.72 ± 0.09 1.59 ± 0.43*
GABAγ1 0.062 ± 0.006 0.26 ± 0.03***
Grin2a 0.27 ± 0.08 0.14 ± 0.007  
Grin2b 1.35 ± 0.26 0.82 ± 0.06  
Grin3A 0.13 ± 0.036 0.29 ± 0.05*
GRIN1 0.07 ± 0.007 0.18 ± 0.04**
GRIA1 1.03 ± 0.14 3.51 ± 1.04*
Vglut1 0.06 ± 0.009 0.004 ± 0.002**
Vglut2 0.1 ± 0.04 3.11 ± 0.85**
  1. *p <  0.05; **p < 0.01; ***p < 0.001 (unpaired t test)