Target gene | RNA abundance (mean ± SEM) | Change | |
---|---|---|---|
Control neurons | TSC neurons | ||
GABAergic cells | |||
DLX1 | 0.016 ± 0.009 | 0.002 ± 0.0004 |  |
DLX2 | 0.03 ± 0.01 | 0.05 ± 0.01 |  |
LHX6 | 0.08 ± 0.02 | 0.11 ± 0.02 |  |
VGAT | 0.03 ± 0.01 | 0.04 ± 0.01 |  |
Synaptic | |||
PSD95 | 0.21 ± 0.05 | 0.12 ± 0.02 |  |
Synaptophysin | 0.07 ± 0.01 | 0.11 ± 0.03 |  |
Homer1 | 0.37 ± 0.07 | 0.43 ± 0.05 |  |
GABA/glutamate signalling | |||
GAD65 | 0.034 ± 0.02 | 0.17 ± 0.07* | ↑ |
GAD67 | 0.13 ± 0.07 | 1.74 ± 0.61** | ↑ |
GABAα1 | 0.33 ± 0.05 | 0.50 ± 0.02 |  |
GABAα2 | 0.31 ± 0.06 | 1.14 ± 0.07*** | ↑ |
GABAβ1 | 0.72 ± 0.09 | 1.59 ± 0.43* | ↑ |
GABAγ1 | 0.062 ± 0.006 | 0.26 ± 0.03*** | ↑ |
Grin2a | 0.27 ± 0.08 | 0.14 ± 0.007 |  |
Grin2b | 1.35 ± 0.26 | 0.82 ± 0.06 |  |
Grin3A | 0.13 ± 0.036 | 0.29 ± 0.05* | ↑ |
GRIN1 | 0.07 ± 0.007 | 0.18 ± 0.04** | ↑ |
GRIA1 | 1.03 ± 0.14 | 3.51 ± 1.04* | ↑ |
Vglut1 | 0.06 ± 0.009 | 0.004 ± 0.002** | ↓ |
Vglut2 | 0.1 ± 0.04 | 3.11 ± 0.85** | ↑ |